HCSGD entry for NFYA
1. General information
| Official gene symbol | NFYA |
|---|---|
| Entrez ID | 4800 |
| Gene full name | nuclear transcription factor Y, alpha |
| Other gene symbols | CBF-A CBF-B HAP2 NF-YA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0016602 | CCAAT-binding factor complex | IDA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0534890620 | 0.8816855515 | 0.5053483513 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1968140505 |
| GSE13712_SHEAR | Up | 0.1726621076 |
| GSE13712_STATIC | Up | 0.1682885108 |
| GSE19018 | Down | -0.2787174643 |
| GSE19899_A1 | Up | 0.4712911960 |
| GSE19899_A2 | Up | 0.6499286535 |
| PubMed_21979375_A1 | Up | 0.8385880916 |
| PubMed_21979375_A2 | Up | 0.7331875399 |
| GSE35957 | Down | -0.3033756992 |
| GSE36640 | Down | -0.3208867612 |
| GSE54402 | Up | 0.6648795093 |
| GSE9593 | Down | -0.1937097335 |
| GSE43922 | Up | 0.7876224023 |
| GSE24585 | Down | -0.4391136338 |
| GSE37065 | Up | 0.0844709982 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0328215025 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-140-3p | MIMAT0004597 | MIRT021682 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025877 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026722 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046947 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25406515 | Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription factor NF-YA to either promote or suppress senescence |
| 25406515 | However, in senescent cells where PANDA sequesters transcription factor NF-YA and limits the expression of NF-YA-E2F-coregulated proliferation-promoting genes, PANDA depletion leads to an exit from senescence |
| 12362892 | In fact, the activities of NF-Y and E2F decrease during ageing and a dominant negative NF-YA induces SA-gal |
| 11707903 | Possible role of subunit A of nuclear factor Y (NF-YA) in normal human diploid fibroblasts during senescence |
| 11707903 | The mRNA levels of NF-YA, B, and C did not show any age-dependent change |
| 11707903 | In contrast, the protein level of NF-YA exhibited a significant and progressive decrease during cell senescence |
| 11707903 | Co-transfection of cells with plasmid encoding NF-YA protein enhanced the expression of reporter gene fused with G1/S gene promoter that contains NF-Y sites |
| 11707903 | In contrast, co-transfection with plasmid encoding the dominant negative NF-YA mutant suppressed the expression of the reporter genes |
| 11707903 | Transient transfection of human cells with dominant negative NF-YA mutant could lead to an increase in neutral beta-galactosidase activity, a marker of cell senescence |
| 8864061 | Both NF-YA and NF-YB were constitutively expressed at mRNA level in IMR-90 cells |
| 8864061 | However, expression of NF-YA, and to a lesser degree, NF-YB, at the protein level were clearly age-dependent |
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