HCSGD entry for ACO1

1. General information

Official gene symbolACO1
Entrez ID48
Gene full nameaconitase 1, soluble
Other gene symbolsACONS IREB1 IREBP IREBP1 IRP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003723RNA bindingIDA NASmolecular_function
GO:0003994Aconitate hydratase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA NAScellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006099Tricarboxylic acid cycleIEAbiological_process
GO:0006101Citrate metabolic processIDAbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0006879Cellular iron ion homeostasisIEAbiological_process
GO:0008152Metabolic processIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010040Response to iron(II) ionIDAbiological_process
GO:0030350Iron-responsive element bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050892Intestinal absorptionIEAbiological_process
GO:00515394 iron, 4 sulfur cluster bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52703927280.06861737020.99999024730.4945448521

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2893990501
GSE13712_SHEARDown-0.8177029375
GSE13712_STATICDown-0.1547424576
GSE19018Down-0.1848118963
GSE19899_A1Down-0.4898337115
GSE19899_A2Down-0.1713887652
PubMed_21979375_A1Down-0.2437024732
PubMed_21979375_A2Down-0.0146410684
GSE35957Up0.3375211049
GSE36640Down-0.0271054115
GSE54402Down-0.5492813716
GSE9593Up0.0334319938
GSE43922Up0.0166026796
GSE24585Down-0.1608589725
GSE37065Up0.0162595608
GSE28863_A1Up0.5379839398
GSE28863_A2Up0.1197364620
GSE28863_A3Down-0.4035352783
GSE28863_A4Up0.1369413613
GSE48662Down-0.4030229572

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.