HCSGD entry for NFKBIB

1. General information

Official gene symbolNFKBIB
Entrez ID4793
Gene full namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Other gene symbolsIKBB TRIP9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53481976750.58559941110.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0839431683
GSE13712_SHEARDown-0.0198787219
GSE13712_STATICDown-0.1612530114
GSE19018Up0.0157997181
GSE19899_A1Up0.0562253716
GSE19899_A2Up0.2449341313
PubMed_21979375_A1Down-0.2270603052
PubMed_21979375_A2Down-0.0027552602
GSE35957Down-0.0161585672
GSE36640Up0.0241065752
GSE54402Up0.3883304505
GSE9593Up0.2109057353
GSE43922Up0.0427971752
GSE24585Down-0.2510680671
GSE37065Up0.2072044047
GSE28863_A1Down-0.4623277803
GSE28863_A2Down-0.2324391503
GSE28863_A3Down-0.0448442831
GSE28863_A4Up0.0147636839
GSE48662Up0.1968971859

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19801829The inhibition of H(2)O(2)-induced cell death by clitocybins was mediated by the reduction of caspase 3 and 9 activation, cytochrome c release from mitochondria and the degradation of IkappaB-alpha and IkappaB-beta, which could be resulted in the prevention of cellular senescence
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