HCSGD entry for NFKBIA

1. General information

Official gene symbolNFKBIA
Entrez ID4792
Gene full namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Other gene symbolsIKBA MAD-3 NFKBI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0007253Cytoplasmic sequestering of NF-kappaBIEA IMPbiological_process
GO:0008134Transcription factor bindingTASmolecular_function
GO:0008139Nuclear localization sequence bindingIPImolecular_function
GO:0010745Negative regulation of macrophage derived foam cell differentiationIMPbiological_process
GO:0010875Positive regulation of cholesterol effluxIMPbiological_process
GO:0010888Negative regulation of lipid storageIMPbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0031072Heat shock protein bindingIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032270Positive regulation of cellular protein metabolic processIMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032495Response to muramyl dipeptideIEAbiological_process
GO:0033256I-kappaB/NF-kappaB complexTAScellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayIEA TASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042345Regulation of NF-kappaB import into nucleusNASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042994Cytoplasmic sequestering of transcription factorIDAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0043392Negative regulation of DNA bindingNASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIEAbiological_process
GO:0045746Negative regulation of Notch signaling pathwayIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0051059NF-kappaB bindingIDA IEA IPImolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0070417Cellular response to coldNASbiological_process
GO:0070427Nucleotide-binding oligomerization domain containing 1 signaling pathwayIEAbiological_process
GO:0070431Nucleotide-binding oligomerization domain containing 2 signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01434211090.79741664070.29700920541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6261376736
GSE13712_SHEARDown-0.3511598159
GSE13712_STATICDown-0.0555204057
GSE19018Down-0.1646662185
GSE19899_A1Down-0.0320109905
GSE19899_A2Up0.9509938702
PubMed_21979375_A1Up0.9430727984
PubMed_21979375_A2Up0.5852921494
GSE35957Down-0.0892490950
GSE36640Down-0.8007972594
GSE54402Up0.7857760145
GSE9593Down-0.2407379508
GSE43922Up0.4046983479
GSE24585Up1.3548224750
GSE37065Up0.8330001846
GSE28863_A1Up0.2492873169
GSE28863_A2Up0.0160712691
GSE28863_A3Down-0.0869341229
GSE28863_A4Up0.1129738767
GSE48662Down-0.1921174153

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30e-3pMIMAT0000693MIRT006695Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22156201
hsa-miR-335-5pMIMAT0000765MIRT017719MicroarrayFunctional MTI (Weak)18185580
hsa-miR-24-3pMIMAT0000080MIRT030500MicroarrayFunctional MTI (Weak)19748357
hsa-let-7b-5pMIMAT0000063MIRT052129CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27041570We show that HOTAIR regulates activation of NF-kappaB by decreasing Ikappa-Balpha (NF-kappaB inhibitor) and establish that by inducing prolonged NF-kappaB activation and expression of NF-kappaB target genes during DNA damage, HOTAIR has a critical role in cellular senescence and platinum sensitivity
25255445The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IkappaBalpha in a manner dependent on IkappaB kinase (IKK) beta and the IKK regulatory subunit NEMO
24403591When NF-kappaB activity is blocked by a degradation-resistant form of IkappaBalpha, DeltaN-IkappaBalpha, Tax-induced senescence is averted
22740410Inhibition of NF-kappaB activation by expression of I-kappaBalpha superrepressor or by small hairpin RNA (shRNA)-mediated knockdown of p65/RelA rescues cells from Tax-induced rapid senescence (Tax-IRS)
22740410Consistent with a critical role of IKKalpha in the transcriptional activity of NF-kappaB, IKKalpha deficiency drastically decreased NF-kappaB trans-activation by Tax, although it only modestly reduced Tax-mediated I-kappaBalpha degradation and NF-kappaB nuclear localization
22390170In the present study, DEK and IkappaBalpha [inhibitor of NF-kappaB (nuclear factor kappaB) alpha] shRNAs (short hairpin RNAs) were constructed and transfected into CaSki cells using Lipofectamine
22390170Following the silencing of DEK and IkappaBalpha, cell proliferation was inhibited, apoptosis was increased, the cell cycle was blocked in the G0/G1-phase with a corresponding decrease in the G2/M-phase, and cell senescence was induced
22074157Phosphorylation of IkappaBalpha and IkappaB total were measured by ELISA
21552325Senescence induced by Tax in HeLa cells is attenuated by mutations in Tax that reduce IKK/NF-kappaB activation and prevented by blocking NF-kappaB using a degradation-resistant mutant of I-kappaBalpha despite constitutive IKK activation
20937593Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines
19801829The inhibition of H(2)O(2)-induced cell death by clitocybins was mediated by the reduction of caspase 3 and 9 activation, cytochrome c release from mitochondria and the degradation of IkappaB-alpha and IkappaB-beta, which could be resulted in the prevention of cellular senescence
16798746Moreover, cotreatment with an IkappaBalpha phosphorylation inhibitor, BAY-11-7082, or a specific NFkappaB nuclear translocation inhibitor, SN50, significantly attenuated the raloxifene-induced telomerase activity and the association of NFkappaB with hTERT
10094826Cytoplasmic IkappaBalpha showed a marked decrease at protein level but an increase in phosphorylation after UVB treatment
8809053The protein levels of inhibitory I kappa B-alpha and Bcl-3 components were not affected by aging in any of the tissues studied
8809053Cellular senescence also slightly decreased the protein levels of I kappa B-alpha and Bcl-3
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