HCSGD entry for NFKB2

1. General information

Official gene symbolNFKB2
Entrez ID4791
Gene full namenuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Other gene symbolsH2TF1 LYT-10 LYT10 NF-kB2 p105 p52
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002268Follicular dendritic cell differentiationIEAbiological_process
GO:0002467Germinal center formationIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0033257Bcl3/NF-kappaB2 complexIDAcellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048536Spleen developmentIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04445042360.97085494470.46938134781.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0533916037
GSE13712_SHEARDown-0.0402556438
GSE13712_STATICDown-0.0891350252
GSE19018Down-0.0824941971
GSE19899_A1Up0.0383285073
GSE19899_A2Up0.5088545796
PubMed_21979375_A1Up0.6782800725
PubMed_21979375_A2Up0.3757855911
GSE35957Down-0.4357040632
GSE36640Up0.1475208490
GSE54402Up0.2209098299
GSE9593Up0.5241933235
GSE43922Up1.0756880892
GSE24585Down-0.0468172497
GSE37065Up0.5864494930
GSE28863_A1Up0.0132871999
GSE28863_A2Up0.1239899981
GSE28863_A3Up0.2146912329
GSE28863_A4Up0.0241862134
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlucosamineDB01296 EXPT01563
HE3286DB05212 -
P54DB05451 -
NOX-700DB05464 -
SGN-30DB05471 -
CC-8490DB05487 -
HMPL-004DB05767 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016350MicroarrayFunctional MTI (Weak)20304954
hsa-miR-98-5pMIMAT0000096MIRT027644MicroarrayFunctional MTI (Weak)19088304
hsa-miR-423-5pMIMAT0004748MIRT038120CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25255445Here we demonstrate that in primary human fibroblasts, the alternative NF-kappaB pathway subunits NF-kappaB2 and RelB have multiple, but distinct, effects on the expression of key regulators of the cell cycle, reactive oxygen species (ROS) generation and protein stability
25255445Specifically, following siRNA knockdown, quantitative PCR, western blot analyses and chromatin immunoprecipitation (ChIP) show that NF-kappaB2 regulates the expression of CDK4 and CDK6, while RelB, through the regulation of genes such as PSMA5 and ANAPC1, regulates the stability of p21WAF1 and the tumour suppressor p53
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