HCSGD entry for NFIX
1. General information
| Official gene symbol | NFIX |
|---|---|
| Entrez ID | 4784 |
| Gene full name | nuclear factor I/X (CCAAT-binding transcription factor) |
| Other gene symbols | MRSHSS NF1A SOTOS2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA TAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0021680 | Cerebellar Purkinje cell layer development | IEA | biological_process |
| GO:0021707 | Cerebellar granule cell differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0048708 | Astrocyte differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8455385092 | 0.0085356521 | 0.9999902473 | 0.1849068627 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2338348522 |
| GSE13712_SHEAR | Down | -0.6004153078 |
| GSE13712_STATIC | Down | -0.3245386699 |
| GSE19018 | Down | -0.0000558111 |
| GSE19899_A1 | Down | -0.5627650467 |
| GSE19899_A2 | Down | -0.9169133618 |
| PubMed_21979375_A1 | Down | -1.1212398547 |
| PubMed_21979375_A2 | Down | -0.4185327121 |
| GSE35957 | Up | 0.0822704434 |
| GSE36640 | Down | -0.3026121146 |
| GSE54402 | Down | -0.7400589660 |
| GSE9593 | Up | 0.0936562215 |
| GSE43922 | Down | -1.4898184702 |
| GSE24585 | Down | -0.7218844335 |
| GSE37065 | Down | -0.4027563763 |
| GSE28863_A1 | Up | 0.6729657766 |
| GSE28863_A2 | Up | 0.4452626279 |
| GSE28863_A3 | Up | 0.1328542232 |
| GSE28863_A4 | Up | 0.0242265841 |
| GSE48662 | Up | 0.8703493570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-223-3p | MIMAT0000280 | MIRT004316 | Luciferase reporter assay | Functional MTI | 19850724 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023216 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043206 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045644 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | NA | hsa-miR-146a | 19944095 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
