HCSGD entry for NFE2L1
1. General information
| Official gene symbol | NFE2L1 |
|---|---|
| Entrez ID | 4779 |
| Gene full name | nuclear factor (erythroid-derived 2)-like 1 |
| Other gene symbols | LCR-F1 NRF1 TCF11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003712 | Transcription cofactor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006783 | Heme biosynthetic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030218 | Erythrocyte differentiation | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0516869762 | 0.6851633335 | 0.4981318332 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0753816820 |
| GSE13712_SHEAR | Down | -0.0592142526 |
| GSE13712_STATIC | Down | -0.0755252630 |
| GSE19018 | Up | 0.8980545888 |
| GSE19899_A1 | Down | -0.6120360959 |
| GSE19899_A2 | Up | 0.0535523412 |
| PubMed_21979375_A1 | Down | -0.0988400845 |
| PubMed_21979375_A2 | Down | -0.6179432238 |
| GSE35957 | Up | 0.1885916116 |
| GSE36640 | Up | 0.4935672632 |
| GSE54402 | Down | -0.2389317043 |
| GSE9593 | Up | 1.0983554406 |
| GSE43922 | Down | -0.2209199369 |
| GSE24585 | Up | 0.4990861208 |
| GSE37065 | Up | 0.1190133609 |
| GSE28863_A1 | Up | 0.2137579145 |
| GSE28863_A2 | Up | 0.5322213915 |
| GSE28863_A3 | Down | -0.0022436497 |
| GSE28863_A4 | Up | 0.1101723479 |
| GSE48662 | Up | 0.5017274829 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Lauryl Dimethylamine-N-Oxide | DB04147 | EXPT02013 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-218-5p | MIMAT0000275 | MIRT003707 | qRT-PCR//Microarray | Functional MTI (Weak) | 19168627 |
| hsa-miR-342-5p | MIMAT0004694 | MIRT038213 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040917 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042231 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042976 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045341 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047968 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048700 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049229 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052755 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
