HCSGD entry for NFE2
1. General information
| Official gene symbol | NFE2 |
|---|---|
| Entrez ID | 4778 |
| Gene full name | nuclear factor (erythroid-derived 2), 45kDa |
| Other gene symbols | NF-E2 p45 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006337 | Nucleosome disassembly | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007599 | Hemostasis | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016605 | PML body | IEA | cellular_component |
| GO:0030502 | Negative regulation of bone mineralization | IEA | biological_process |
| GO:0034242 | Negative regulation of syncytium formation by plasma membrane fusion | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA TAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | TAS | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
| GO:0050699 | WW domain binding | IDA IPI | molecular_function |
| GO:0060716 | Labyrinthine layer blood vessel development | IEA | biological_process |
| GO:2000758 | Positive regulation of peptidyl-lysine acetylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8644578587 | 0.3707327799 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0413624329 |
| GSE13712_SHEAR | Up | 0.1626820597 |
| GSE13712_STATIC | Down | -0.0606971593 |
| GSE19018 | Down | -0.0399587877 |
| GSE19899_A1 | Up | 0.0569399666 |
| GSE19899_A2 | Up | 0.0133045217 |
| PubMed_21979375_A1 | Up | 0.2648751920 |
| PubMed_21979375_A2 | Up | 0.1336554465 |
| GSE35957 | Down | -0.2335074988 |
| GSE36640 | Down | -0.0710615651 |
| GSE54402 | Down | -0.0818387864 |
| GSE9593 | Up | 0.0419770166 |
| GSE43922 | Up | 0.0242141093 |
| GSE24585 | Down | -0.0279084567 |
| GSE37065 | Down | -0.2171843672 |
| GSE28863_A1 | Down | -0.1187519149 |
| GSE28863_A2 | Down | -0.0999066709 |
| GSE28863_A3 | Up | 0.0176547754 |
| GSE28863_A4 | Down | -0.0210563755 |
| GSE48662 | Down | -0.2804962580 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9141625 | They also expressed RNA for beta-globin, GATA-1, and NF-E2 |
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