HCSGD entry for NFATC4

1. General information

Official gene symbolNFATC4
Entrez ID4776
Gene full namenuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Other gene symbolsNF-ATc4 NFAT3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034644Cellular response to UVIEAbiological_process
GO:0042975Peroxisome proliferator activated receptor bindingIEAmolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0045333Cellular respirationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0055001Muscle cell developmentIEAbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:2001235Positive regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34196411230.21010718060.99999024730.8855454123

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1680464924
GSE13712_SHEARDown-0.5261676269
GSE13712_STATICUp0.0802294649
GSE19018Up0.1573286185
GSE19899_A1Down-0.0011092285
GSE19899_A2Down-0.3807441359
PubMed_21979375_A1Down-0.7952642667
PubMed_21979375_A2Up0.0280099835
GSE35957Down-0.1925998910
GSE36640Up0.1108167533
GSE54402Down-0.0312877532
GSE9593Down-0.2583568393
GSE43922Up0.1391828652
GSE24585Up0.1840895696
GSE37065Down-0.2180799056
GSE28863_A1Up0.5047174191
GSE28863_A2Up0.5143196446
GSE28863_A3Down-0.0922006032
GSE28863_A4Down-0.0730759230
GSE48662Up0.3483894067

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.