HCSGD entry for NEUROD1

1. General information

Official gene symbolNEUROD1
Entrez ID4760
Gene full nameneuronal differentiation 1
Other gene symbolsBETA2 BHF-1 MODY6 NEUROD bHLHa3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0003326Pancreatic A cell fate commitmentIEAbiological_process
GO:0003329Pancreatic PP cell fate commitmentIEAbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006913Nucleocytoplasmic transportIEAbiological_process
GO:0007263Nitric oxide mediated signal transductionIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0009749Response to glucoseIMPbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0021542Dentate gyrus developmentISSbiological_process
GO:0021549Cerebellum developmentISSbiological_process
GO:0022008NeurogenesisTASbiological_process
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030073Insulin secretionIDAbiological_process
GO:0031018Endocrine pancreas developmentISS TASbiological_process
GO:0035881Amacrine cell differentiationISSbiological_process
GO:0035883Enteroendocrine cell differentiationISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0043065Positive regulation of apoptotic processISSbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045597Positive regulation of cell differentiationISSbiological_process
GO:0045666Positive regulation of neuron differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046426Negative regulation of JAK-STAT cascadeIEAbiological_process
GO:0046982Protein heterodimerization activityIDA IPImolecular_function
GO:0048562Embryonic organ morphogenesisISSbiological_process
GO:0048839Inner ear developmentISSbiological_process
GO:0050796Regulation of insulin secretionICbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0060730Regulation of intestinal epithelial structure maintenanceISSbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071156Regulation of cell cycle arrestISSbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:2000675Negative regulation of type B pancreatic cell apoptotic processISSbiological_process
GO:2000679Positive regulation of transcription regulatory region DNA bindingIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.47901497280.90291776150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0274224717
GSE13712_SHEARDown-0.0853216231
GSE13712_STATICUp0.1388672933
GSE19018Up0.1648324810
GSE19899_A1Up0.0081108523
GSE19899_A2Down-0.1401155404
PubMed_21979375_A1Up0.0541626876
PubMed_21979375_A2Up0.0020769595
GSE35957Up0.1134200405
GSE36640Up0.0123646880
GSE54402Up0.0892378452
GSE9593Down-0.0699954396
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0558594350
GSE28863_A2Up0.4414823248
GSE28863_A3Down-0.0851766936
GSE28863_A4Up0.3307232385
GSE48662Down-0.0454395369

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT007297Western blotFunctional MTI23338554
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24402692In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer
18025081DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
18025081Among the many candidates is DEC1, a basic helix-loop-helix transcription factor that has been recently shown to be up-regulated in K-ras-induced premature senescence
17690110Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival
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