HCSGD entry for NEK1
1. General information
| Official gene symbol | NEK1 |
|---|---|
| Entrez ID | 4750 |
| Gene full name | NIMA-related kinase 1 |
| Other gene symbols | NY-REN-55 SRPS2 SRPS2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000242 | Pericentriolar material | IDA | cellular_component |
| GO:0004672 | Protein kinase activity | IDA IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0010212 | Response to ionizing radiation | IEA | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0042384 | Cilium assembly | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7696771893 | 0.4960758520 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0199403537 |
| GSE13712_SHEAR | Up | 0.0384436635 |
| GSE13712_STATIC | Down | -0.0119492049 |
| GSE19018 | Up | 0.0792804808 |
| GSE19899_A1 | Up | 0.1415455141 |
| GSE19899_A2 | Down | -0.3774366645 |
| PubMed_21979375_A1 | Down | -0.1755178799 |
| PubMed_21979375_A2 | Down | -0.0872716251 |
| GSE35957 | Down | -0.1527526147 |
| GSE36640 | Down | -0.0341989602 |
| GSE54402 | Down | -0.2598537903 |
| GSE9593 | Up | 0.0540713275 |
| GSE43922 | Up | 0.0265259242 |
| GSE24585 | Up | 0.0945605498 |
| GSE37065 | Up | 0.1213592941 |
| GSE28863_A1 | Up | 0.4095695321 |
| GSE28863_A2 | Up | 0.2121281644 |
| GSE28863_A3 | Down | -0.5232925597 |
| GSE28863_A4 | Down | -0.1675169463 |
| GSE48662 | Down | -0.0012634228 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT026517 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030894 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-484 | MIMAT0002174 | MIRT042284 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
