HCSGD entry for NEFL
1. General information
| Official gene symbol | NEFL |
|---|---|
| Entrez ID | 4747 |
| Gene full name | neurofilament, light polypeptide |
| Other gene symbols | CMT1F CMT2E NF-L NF68 NFL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005200 | Structural constituent of cytoskeleton | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005883 | Neurofilament | IDA | cellular_component |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008089 | Anterograde axon cargo transport | IMP | biological_process |
| GO:0008090 | Retrograde axon cargo transport | IMP | biological_process |
| GO:0019896 | Axon transport of mitochondrion | IMP | biological_process |
| GO:0030424 | Axon | IDA | cellular_component |
| GO:0033596 | TSC1-TSC2 complex | IDA | cellular_component |
| GO:0033693 | Neurofilament bundle assembly | IDA IMP | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045109 | Intermediate filament organization | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0003335132 | 0.9208110938 | 0.0490413408 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.0289146741 |
| GSE13712_SHEAR | Up | 0.0028360409 |
| GSE13712_STATIC | Down | -0.0144821829 |
| GSE19018 | Up | 0.0116096549 |
| GSE19899_A1 | Up | 0.5671618208 |
| GSE19899_A2 | Up | 2.9390341054 |
| PubMed_21979375_A1 | Up | 6.4006930737 |
| PubMed_21979375_A2 | Up | 4.7454574668 |
| GSE35957 | Up | 0.1470901780 |
| GSE36640 | Up | 0.2702710547 |
| GSE54402 | Up | 2.9840765216 |
| GSE9593 | Up | 0.1108339052 |
| GSE43922 | Up | 1.0188535438 |
| GSE24585 | Down | -1.1475251332 |
| GSE37065 | Up | 0.1081317312 |
| GSE28863_A1 | Down | -0.1422650314 |
| GSE28863_A2 | Up | 0.0278090796 |
| GSE28863_A3 | Up | 0.4376073012 |
| GSE28863_A4 | Up | 0.2125909311 |
| GSE48662 | Down | -0.0282240989 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-32-5p | MIMAT0000090 | MIRT028294 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23145129 | The loss of NFl from the endothelium is embryonically lethal in mouse developmental models, however little is known regarding the molecular regulation by NF1 in endothelium |
| 16306232 | Down-regulation of the candidate neuron-specific genes for N-methyl-D-aspartate (NMDA) receptor subunits (NMDAzeta1 and -epsilon2) and neurofilament light peptide (NF-L) were found to be characteristic of the aging process as reported in vivo (Brain Res 907:71-83, 2001; Brain Res Mol Brain Res 99:40-45, 2002) |
| 16306232 | Inhibition of heme synthesis (by 70-80%) at different enzymic steps by succinyl acetone and N-methylprotoporphyrin IX resulted in the earlier lowered expression of NMDAzeta1 and -epsilon2 and NF-L |
| 16306232 | Culture of cortical neurons from BALB/c Fech(m1Pas) mutant mice demonstrating depressed heme synthesis showed premature senescence and reduced expression of NMDAzeta1 and -epsilon2 receptor subunits and NF-L compared with wild-type cells |
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