HCSGD entry for NEDD8

1. General information

Official gene symbolNEDD8
Entrez ID4738
Gene full nameneural precursor cell expressed, developmentally down-regulated 8
Other gene symbolsNEDD-8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0006464Cellular protein modification processTASbiological_process
GO:0006508ProteolysisTASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0045116Protein neddylationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04236107670.84419238250.45997768151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3068249962
GSE13712_SHEARDown-0.0093403134
GSE13712_STATICUp0.0211252033
GSE19018Up0.2738346312
GSE19899_A1Down-0.0418808602
GSE19899_A2Up0.0278865329
PubMed_21979375_A1Down-0.3079722784
PubMed_21979375_A2Down-0.2530465568
GSE35957Down-0.2399164482
GSE36640Down-0.0257392543
GSE54402Up0.0808742815
GSE9593Up0.1755512291
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.2433968091
GSE28863_A2Up0.8277668362
GSE28863_A3Up1.3582451739
GSE28863_A4Up0.5576120553
GSE48662Up0.0206805602

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26003431STUDY DESIGN, SIZE, DURATION: We first analyzed the expression of NEDD8 in human endometrial tissues from 50 subjects, and then explored the consequence of neddylation inhibition by MLN4924 on HESCs proliferation, decidualization and cellular senescence
26003431PARTICIPANTS/MATERIALS, SETTING, METHODS: We collected 50 dated human endometrial tissues from early proliferative stage to late secretory phase of the menstrual cycle and analyzed the NEDD8 expression and cellular location in human endometrium by employing quantitative real-time PCR (qRT-PCR) and immunohistochemistry staining
26003431Similar approaches were also used to explore the mRNA and protein expression of NEDD8 in an immortalized human endometrial stromal cell line (HESC) during proliferation and decidualization (N = 6)
26003431MAIN RESULTS AND THE ROLE OF CHANCE: We demonstrated that NEDD8 is ubiquitously expressed in human endometrium including luminal epithelium, glandular epithelium and the stromal cells during the menstrual cycle, as well as in the HESCs during proliferation and differentiation in culture
26003431LIMITATIONS, REASONS FOR CAUTION: Since NEDD8 was also intensely expressed in the endometrial epithelium, it is interesting to further study its potential role in stroma-epithelial interactions through isolating and culturing epithelial cells
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