HCSGD entry for NDUFA8
1. General information
| Official gene symbol | NDUFA8 |
|---|---|
| Entrez ID | 4702 |
| Gene full name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa |
| Other gene symbols | CI-19KD CI-PGIV PGIV |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0005747 | Mitochondrial respiratory chain complex I | IDA NAS | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA | cellular_component |
| GO:0006120 | Mitochondrial electron transport, NADH to ubiquinone | NAS | biological_process |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | NAS | molecular_function |
| GO:0022904 | Respiratory electron transport chain | TAS | biological_process |
| GO:0032403 | Protein complex binding | IDA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2183399529 | 0.7725335512 | 0.8987997967 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3933618092 |
| GSE13712_SHEAR | Down | -0.4635581233 |
| GSE13712_STATIC | Down | -0.0106264717 |
| GSE19018 | Up | 0.3068167117 |
| GSE19899_A1 | Up | 0.1817857976 |
| GSE19899_A2 | Up | 0.4011260299 |
| PubMed_21979375_A1 | Down | -0.2729803113 |
| PubMed_21979375_A2 | Up | 0.2791444842 |
| GSE35957 | Down | -0.3950781948 |
| GSE36640 | Down | -0.0231907701 |
| GSE54402 | Up | 0.2787378459 |
| GSE9593 | Down | -0.1412606133 |
| GSE43922 | Up | 0.0824893969 |
| GSE24585 | Down | -0.2656825812 |
| GSE37065 | Down | -0.0449029879 |
| GSE28863_A1 | Up | 0.1120437249 |
| GSE28863_A2 | Up | 0.2097426198 |
| GSE28863_A3 | Down | -0.0076974588 |
| GSE28863_A4 | Up | 0.1858582607 |
| GSE48662 | Down | -0.0711626485 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18977241 | Telomere lengths were calculated for 190 (82 men, 108 women) participants aged 79 years and associations with 384 SNPs, from 141 oxidative stress genes, identified 9 significant SNPS, of which those from 5 genes (GSTZ1, MSRA, NDUFA3, NDUFA8, VIM) had robust associations with physical aging biomarkers, respiratory function or grip strength |
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