HCSGD entry for NDN
1. General information
| Official gene symbol | NDN |
|---|---|
| Entrez ID | 4692 |
| Gene full name | necdin, melanoma antigen (MAGE) family member |
| Other gene symbols | HsT16328 PWCR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0003016 | Respiratory system process | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005813 | Centrosome | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007413 | Axonal fasciculation | IEA | biological_process |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0008347 | Glial cell migration | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0019233 | Sensory perception of pain | IEA | biological_process |
| GO:0040008 | Regulation of growth | IEA | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043015 | Gamma-tubulin binding | IEA | molecular_function |
| GO:0043204 | Perikaryon | IEA | cellular_component |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | IEA | biological_process |
| GO:0048675 | Axon extension | IEA | biological_process |
| GO:0048871 | Multicellular organismal homeostasis | IEA | biological_process |
| GO:0071514 | Genetic imprinting | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9340999430 | 0.0015566430 | 0.9999902473 | 0.0760460111 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0960716985 |
| GSE13712_SHEAR | Down | -6.0038163984 |
| GSE13712_STATIC | Down | -5.4924787687 |
| GSE19018 | Down | -0.0504809041 |
| GSE19899_A1 | Down | -1.5058749603 |
| GSE19899_A2 | Up | 0.0181618018 |
| PubMed_21979375_A1 | Down | -0.4123161979 |
| PubMed_21979375_A2 | Down | -0.4927984714 |
| GSE35957 | Down | -0.6620633050 |
| GSE36640 | Down | -0.0385361646 |
| GSE54402 | Down | -0.0976112192 |
| GSE9593 | Down | -0.0630177810 |
| GSE43922 | Down | -0.0328921919 |
| GSE24585 | Down | -0.0562638587 |
| GSE37065 | Down | -0.0448637062 |
| GSE28863_A1 | Up | 0.1017709314 |
| GSE28863_A2 | Down | -0.6611677588 |
| GSE28863_A3 | Down | -0.0515437997 |
| GSE28863_A4 | Up | 0.0558609813 |
| GSE48662 | Up | 0.3911564891 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019333 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22691188 | Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress |
| 22691188 | Necdin interacts with p53 and is also a p53 target gene, although the importance of Necdin in the p53 response is not clearly understood |
| 22691188 | METHODS: In this study, we first investigated Necdin protein expression during replicative senescence and premature senescence induced by gamma irradiation and by the overexpression of oncogenic RasV12 |
| 22691188 | Gain and loss of function experiments were used to evaluate the contribution of Necdin during the senescence process |
| 22691188 | RESULTS: Necdin expression declined during replicative aging of IMR90 primary human fibroblasts or following induction of premature senescence |
| 22691188 | Decrease in Necdin expression seemed to be a consequence of the establishment of senescence since the depletion of Necdin in human cells did not induce a senescence-like growth arrest nor a flat morphology or SA-beta-galactosidase activity normally associated with senescence |
| 22691188 | Similarly, overexpression of Necdin did not affect the life span of IMR90 cells |
| 22691188 | However, we demonstrate that in normal human cells, Necdin expression mimicked the effect of p53 inactivation by increasing radioresistance |
| 22691188 | CONCLUSION: This result suggests that Necdin potentially attenuate p53 signaling in response to genotoxic stress in human cells and supports similar results describing an inhibitory function of Necdin over p53-dependent growth arrest in mice |
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