HCSGD entry for NCL
1. General information
| Official gene symbol | NCL |
|---|---|
| Entrez ID | 4691 |
| Gene full name | nucleolin |
| Other gene symbols | C23 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0001525 | Angiogenesis | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA IEA | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0042162 | Telomeric DNA binding | IDA | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5426315452 | 0.4050543748 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0527214443 |
| GSE13712_SHEAR | Down | -0.0421266115 |
| GSE13712_STATIC | Up | 0.0434744930 |
| GSE19018 | Down | -0.3902105994 |
| GSE19899_A1 | Up | 0.1536208497 |
| GSE19899_A2 | Up | 0.1243048205 |
| PubMed_21979375_A1 | Up | 0.1555317108 |
| PubMed_21979375_A2 | Up | 0.0022253451 |
| GSE35957 | Down | -0.0695774078 |
| GSE36640 | Down | -0.2290559990 |
| GSE54402 | Down | -0.0664874173 |
| GSE9593 | Down | -0.2046641692 |
| GSE43922 | Up | 0.0800810916 |
| GSE24585 | Down | -0.2442854920 |
| GSE37065 | Down | -0.1936372718 |
| GSE28863_A1 | Up | 0.4520435559 |
| GSE28863_A2 | Up | 0.5280257958 |
| GSE28863_A3 | Up | 0.2007305658 |
| GSE28863_A4 | Down | -0.1121593013 |
| GSE48662 | Down | -0.4754361185 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005204 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036889 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037670 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039947 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-598-3p | MIMAT0003266 | MIRT040493 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040534 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041552 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046909 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048058 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049002 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25183317 | Transfected GFP-p49/STRAP protein co-localized with nucleolin within the nucleolus |
| 24782448 | Interactions of two highly acetylated proteins, nucleophosmin (NPM1) and nucleolin, with SIRT6 and SIRT7 were confirmed by co-immunoprecipitation |
| 21464199 | Mechanistic studies revealed that CTP depletion induced a rapid translocation of nucleolar proteins, including nucleostemin and nucleolin into the nucleoplasm |
| 19248764 | Using patient derived lymphoblasts from three genetically distinct NCLs we report that AFSM for each NCL has distinct spectral properties |
| 8212965 | Down syndrome (DS) and neuronal ceroid-lypofuscinosis (NCL) are clinically characterized by the premature onset of numerous features normally associated with human aging |
| 8212965 | Phytohemagglutinin stimulated lymphocytes derived from DS subjects showed a statistically significant diminished proliferation capacity in comparison with lymphocytes derived from NCL and healthy individuals |
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