HCSGD entry for NACA

1. General information

Official gene symbolNACA
Entrez ID4666
Gene full namenascent polypeptide-associated complex alpha subunit
Other gene symbolsNACA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003231Cardiac ventricle developmentISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005854Nascent polypeptide-associated complexTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006412TranslationTASbiological_process
GO:0010664Negative regulation of striated muscle cell apoptotic processISSbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0017025TBP-class protein bindingISSmolecular_function
GO:0043403Skeletal muscle tissue regenerationISSbiological_process
GO:0048633Positive regulation of skeletal muscle tissue growthISSbiological_process
GO:0048742Regulation of skeletal muscle fiber developmentISSbiological_process
GO:0061384Heart trabecula morphogenesisISSbiological_process
GO:1901227Negative regulation of transcription from RNA polymerase II promoter involved in heart developmentISSbiological_process
GO:1901228Positive regulation of transcription from RNA polymerase II promoter involved in heart developmentISSbiological_process
GO:2000138Positive regulation of cell proliferation involved in heart morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69885720530.50550126140.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0965750593
GSE13712_SHEARDown-0.2513992054
GSE13712_STATICDown-0.1147674957
GSE19018Down-0.2589638044
GSE19899_A1Up0.1346626468
GSE19899_A2Up0.0347250346
PubMed_21979375_A1Up0.4067130404
PubMed_21979375_A2Up0.3494929081
GSE35957Down-0.4224267534
GSE36640Down-0.1362650711
GSE54402Up0.1420329975
GSE9593Down-0.0711035768
GSE43922Down-0.0218878340
GSE24585Up0.0208720047
GSE37065Down-0.2953718442
GSE28863_A1Up0.1103274250
GSE28863_A2Up0.1358135325
GSE28863_A3Up0.1573838669
GSE28863_A4Up0.0841410090
GSE48662Down-0.2273454054

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT032033ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT037036CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037224CLASHFunctional MTI (Weak)23622248
hsa-miR-671-5pMIMAT0003880MIRT039260CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039822CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045676CLASHFunctional MTI (Weak)23622248
hsa-miR-17-3pMIMAT0000071MIRT050758CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052206CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.