HCSGD entry for MYOG

1. General information

Official gene symbolMYOG
Entrez ID4656
Gene full namemyogenin (myogenic factor 4)
Other gene symbolsMYF4 bHLHc3 myf-4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingISSmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001047Core promoter bindingISSmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionTASmolecular_function
GO:0001503OssificationIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexISScellular_component
GO:0007049Cell cycleIEAbiological_process
GO:0007519Skeletal muscle tissue developmentTASbiological_process
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0010831Positive regulation of myotube differentiationISSbiological_process
GO:0014737Positive regulation of muscle atrophyISSbiological_process
GO:0014842Regulation of satellite cell proliferationISSbiological_process
GO:0014873Response to muscle activity involved in regulation of muscle adaptationISSbiological_process
GO:0014878Response to electrical stimulus involved in regulation of muscle adaptationISSbiological_process
GO:0014891Striated muscle atrophyISSbiological_process
GO:0014894Response to denervation involved in regulation of muscle adaptationISSbiological_process
GO:0031490Chromatin DNA bindingISSmolecular_function
GO:0032993Protein-DNA complexISScellular_component
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042693Muscle cell fate commitmentISSbiological_process
GO:0042789MRNA transcription from RNA polymerase II promoterTASbiological_process
GO:0045663Positive regulation of myoblast differentiationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046982Protein heterodimerization activityISSmolecular_function
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
GO:0048743Positive regulation of skeletal muscle fiber developmentISSbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0070888E-box bindingISSmolecular_function
GO:0071158Positive regulation of cell cycle arrestISSbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071392Cellular response to estradiol stimulusISSbiological_process
GO:1901739Regulation of myoblast fusionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57066443900.57078705980.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0352112586
GSE13712_SHEARDown-0.2225644554
GSE13712_STATICDown-0.3112233676
GSE19018Up0.1225303586
GSE19899_A1Down-0.1263764532
GSE19899_A2Up0.2181150521
PubMed_21979375_A1Down-0.2810616121
PubMed_21979375_A2Down-0.1411038690
GSE35957Up0.0349918143
GSE36640Up0.0899847426
GSE54402Up0.0574100966
GSE9593Up0.0347411919
GSE43922Up0.0948535152
GSE24585Down-0.1397695950
GSE37065Up0.0757890147
GSE28863_A1Down-0.1995519792
GSE28863_A2Up0.3959597154
GSE28863_A3Up0.2233543432
GSE28863_A4Up0.1786153550
GSE48662Up0.0124351623

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030010MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19589617Finally, when transferred to low-serum medium, patient myoblasts were deficient in ex vivo differentiation, as assessed by the absence of myotube formation and myogenin induction
11937715The expression levels of MyoD, myogenin, MHC and p21 were also reduced in these clones
11374435Our results indicate that myf-5 null myoblasts differ from wild type (wt) myoblasts in that they undergo precocious differentiation: they become myogenin- and troponin T-positive and fail to incorporate bromodeoxyuridine (BrdU) under culture conditions and at a time when wt cells are not yet differentiated and continue to proliferate
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