HCSGD entry for MYOC
1. General information
| Official gene symbol | MYOC |
|---|---|
| Entrez ID | 4653 |
| Gene full name | myocilin, trabecular meshwork inducible glucocorticoid response |
| Other gene symbols | GLC1A GPOA JOAG JOAG1 TIGR myocilin |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | TAS | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005791 | Rough endoplasmic reticulum | IEA | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2281269443 | 0.9243308803 | 0.9100124678 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0795822765 |
| GSE13712_SHEAR | Up | 0.0729068128 |
| GSE13712_STATIC | Up | 0.1527305236 |
| GSE19018 | Down | -0.0159417676 |
| GSE19899_A1 | Up | 0.0659831909 |
| GSE19899_A2 | Up | 0.1867273592 |
| PubMed_21979375_A1 | Down | -0.0021502001 |
| PubMed_21979375_A2 | Up | 0.3745956784 |
| GSE35957 | Down | -0.0917525191 |
| GSE36640 | Down | -0.0729412364 |
| GSE54402 | Up | 0.1454064769 |
| GSE9593 | Up | 0.0481873681 |
| GSE43922 | Up | 0.0138019784 |
| GSE24585 | Up | 0.1185274395 |
| GSE37065 | Up | 0.2844941918 |
| GSE28863_A1 | Up | 0.3628174653 |
| GSE28863_A2 | Up | 0.0603379929 |
| GSE28863_A3 | Up | 0.1606444880 |
| GSE28863_A4 | Up | 0.1071071498 |
| GSE48662 | Down | -0.0423078395 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005837 | Microarray | Functional MTI (Weak) | 21282569 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16552252 | Myocilin and the heparin II domain of fibronectin also influence the actin cytoskeleton |
| 16552252 | Mutated myocilin appears to affect trabecular meshwork cells differently from wild-type myocilin and can reduce cell survival |
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