HCSGD entry for MYO6

1. General information

Official gene symbolMYO6
Entrez ID4646
Gene full namemyosin VI
Other gene symbolsDFNA22 DFNB37
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0003774Motor activityIEA ISSmolecular_function
GO:0003779Actin bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingISS TASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0005765Lysosomal membraneTAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005902MicrovillusIEAcellular_component
GO:0005905Coated pitIEAcellular_component
GO:0005938Cell cortexISScellular_component
GO:0006605Protein targetingIEAbiological_process
GO:0006886Intracellular protein transportISSbiological_process
GO:0006897EndocytosisIMP ISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007416Synapse assemblyIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008152Metabolic processISS NASbiological_process
GO:0014047Glutamate secretionIEAbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0016358Dendrite developmentIEAbiological_process
GO:0016459Myosin complexIEAcellular_component
GO:0016461Unconventional myosin complexTAScellular_component
GO:0016591DNA-directed RNA polymerase II, holoenzymeIDAcellular_component
GO:0030048Actin filament-based movementISS NASbiological_process
GO:0030139Endocytic vesicleISScellular_component
GO:0030330DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0030424AxonIEAcellular_component
GO:0030665Clathrin-coated vesicle membraneIEAcellular_component
GO:0031941Filamentous actinIDA ISScellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0032587Ruffle membraneIEAcellular_component
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042491Auditory receptor cell differentiationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043531ADP bindingISSmolecular_function
GO:0045177Apical part of cellIEAcellular_component
GO:0045334Clathrin-coated endocytic vesicleIDAcellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDA ISScellular_component
GO:0051015Actin filament bindingIDA ISSmolecular_function
GO:0051046Regulation of secretionIMPbiological_process
GO:0060001Minus-end directed microfilament motor activityNASmolecular_function
GO:0071257Cellular response to electrical stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11041925080.15935877440.68764697290.7710445404

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2170255291
GSE13712_SHEARUp0.1178138884
GSE13712_STATICDown-0.1584595554
GSE19018Up0.2988696549
GSE19899_A1Down-0.2922102148
GSE19899_A2Down-0.7405809414
PubMed_21979375_A1Down-0.8210757499
PubMed_21979375_A2Down-0.3908234139
GSE35957Up0.3163609573
GSE36640Up0.8941298544
GSE54402Down-0.6552527955
GSE9593Up0.9836992139
GSE43922Down-0.1344516256
GSE24585Up0.3422861934
GSE37065Up0.0923063890
GSE28863_A1Up0.4245564767
GSE28863_A2Up1.1662226003
GSE28863_A3Down-0.1607628382
GSE28863_A4Down-0.0861973665
GSE48662Down-0.2025052070

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT000457qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20353999
hsa-miR-143-3pMIMAT0000435MIRT000458qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20353999
hsa-miR-143-3pMIMAT0000435MIRT000458Western blotFunctional MTI19843160
hsa-miR-335-5pMIMAT0000765MIRT018339MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020824ProteomicsFunctional MTI (Weak)18668040
hsa-miR-324-3pMIMAT0000762MIRT042992CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044611CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049595CLASHFunctional MTI (Weak)23622248
hsa-miR-22-3pMIMAT0000077MIRT050462CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.