HCSGD entry for SERPINC1

1. General information

Official gene symbolSERPINC1
Entrez ID462
Gene full nameserpin peptidase inhibitor, clade C (antithrombin), member 1
Other gene symbolsAT3 AT3D ATIII THPH7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIPImolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIBA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007584Response to nutrientIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008201Heparin bindingIEAmolecular_function
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0030162Regulation of proteolysisIBAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:2000266Regulation of blood coagulation, intrinsic pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67742238900.89824308350.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0164490826
GSE13712_SHEARUp0.0018389661
GSE13712_STATICDown-0.0055294262
GSE19018Down-0.0011271257
GSE19899_A1Up0.1314610997
GSE19899_A2Up0.0385199166
PubMed_21979375_A1Up0.1064497770
PubMed_21979375_A2Up0.0852514045
GSE35957Up0.1011776264
GSE36640Up0.1286052357
GSE54402Down-0.0350414756
GSE9593Up0.1912659105
GSE43922Up0.0102069328
GSE24585Up0.0697360026
GSE37065Down-0.0364673607
GSE28863_A1Down-0.1644976187
GSE28863_A2Up0.0097935225
GSE28863_A3Up0.1167014853
GSE28863_A4Up0.0414317396
GSE48662Up0.0689728405

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ArdeparinDB00407 APRD00803
HeparinDB01109 APRD00056
EnoxaparinDB01225 APRD00068
N-FormylmethionineDB04464 EXPT01455
SR-123781ADB05361 -
SulodexideDB06271 -
TinzaparinDB06822 -
NadroparinDB08813 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.