HCSGD entry for MYF5

1. General information

Official gene symbolMYF5
Entrez ID4617
Gene full namemyogenic factor 5
Other gene symbolsbHLHc2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001503OssificationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001952Regulation of cell-matrix adhesionIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0007519Skeletal muscle tissue developmentTASbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042693Muscle cell fate commitmentISSbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityISSmolecular_function
GO:0048704Embryonic skeletal system morphogenesisIEAbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0060415Muscle tissue morphogenesisIEAbiological_process
GO:0070888E-box bindingISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80993707690.60746834470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1097533892
GSE13712_SHEARDown-0.1438834477
GSE13712_STATICDown-0.0089614671
GSE19018Up0.0054127708
GSE19899_A1Up0.0648212793
GSE19899_A2Up0.0865257802
PubMed_21979375_A1Up0.3171373348
PubMed_21979375_A2Down-0.1341415386
GSE35957Down-0.0045895214
GSE36640Up0.0646783166
GSE54402Down-0.0867756206
GSE9593Up0.0493106783
GSE43922Up0.0011712356
GSE24585Down-0.1903196874
GSE37065Down-0.0607861316
GSE28863_A1Down-0.2257777425
GSE28863_A2Up0.2012272108
GSE28863_A3Down-0.0320589348
GSE28863_A4Up0.0359818920
GSE48662Up0.0779627729

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019252MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

11374435Myf-5 and MyoD are the two muscle regulatory factors expressed from the myoblast stage to maintain the identity and to promote the subsequent differentiation of muscle precursor cells
11374435That a null mutation in either gene reduces the proliferative potential of cultured myoblasts raises the possibility that Myf-5 and MyoD serve proliferation of muscle precursor cells
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