HCSGD entry for MYD88

1. General information

Official gene symbolMYD88
Entrez ID4615
Gene full namemyeloid differentiation primary response 88
Other gene symbolsMYD88D
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002238Response to molecule of fungal originIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA TASbiological_process
GO:0005121Toll bindingIEAmolecular_function
GO:0005123Death receptor bindingTASmolecular_function
GO:0005149Interleukin-1 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolIEA TAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0008063Toll signaling pathwayIEAbiological_process
GO:0009615Response to virusIEAbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016064Immunoglobulin mediated immune responseIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032494Response to peptidoglycanIEAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIEA ISSbiological_process
GO:0032747Positive regulation of interleukin-23 productionIEA ISSbiological_process
GO:0032755Positive regulation of interleukin-6 productionIEA ISSbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEA IEPbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0045080Positive regulation of chemokine biosynthetic processIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045351Type I interferon biosynthetic processIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050671Positive regulation of lymphocyte proliferationIEAbiological_process
GO:0050727Regulation of inflammatory responseIEA ISSbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEA ISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0070555Response to interleukin-1IMPbiological_process
GO:00709353'-UTR-mediated mRNA stabilizationIDAbiological_process
GO:0070976TIR domain bindingIEA IPImolecular_function
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18413332700.22553410580.83908817520.9134670103

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0672277760
GSE13712_SHEARUp0.4744975714
GSE13712_STATICUp0.5390849373
GSE19018Down-0.8376375104
GSE19899_A1Down-0.3710920623
GSE19899_A2Up0.0053985249
PubMed_21979375_A1Down-0.1502313080
PubMed_21979375_A2Up0.2131769373
GSE35957Down-0.4075834575
GSE36640Up0.2065097732
GSE54402Up0.2754715545
GSE9593Down-0.2243160619
GSE43922Down-0.1068075008
GSE24585Up0.2442529557
GSE37065Up0.6415082232
GSE28863_A1Down-0.0080219403
GSE28863_A2Up0.1527389170
GSE28863_A3Down-0.6876704610
GSE28863_A4Down-0.0447376817
GSE48662Down-0.1395377618

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-203aMIMAT0000264MIRT007368Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23522925
hsa-miR-155-5pMIMAT0000646MIRT020533Western blotFunctional MTI21030878
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Western blot}{overexpression by miRNA mimics tranfection}20219467
hsa-miR-155-5pMIMAT0000646NAhsa-miR-155{Western blot}{overexpression}20219467
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.