HCSGD entry for MYCN

1. General information

Official gene symbolMYCN
Entrez ID4613
Gene full namev-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Other gene symbolsMODED N-myc NMYC ODED bHLHe37
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinTAScellular_component
GO:0001502Cartilage condensationIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0010942Positive regulation of cell deathIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048704Embryonic skeletal system morphogenesisIEAbiological_process
GO:0048712Negative regulation of astrocyte differentiationIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87285312490.73903131340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0672027580
GSE13712_SHEARDown-0.2245825333
GSE13712_STATICDown-0.3274667946
GSE19018Up0.0956007522
GSE19899_A1Up0.0229365357
GSE19899_A2Up0.1511353177
PubMed_21979375_A1Up0.0425090984
PubMed_21979375_A2Down-0.0658161654
GSE35957Up0.0772873265
GSE36640Up0.0579334369
GSE54402Down-0.0499351925
GSE9593Down-0.0610440615
GSE43922Up0.0223274157
GSE24585Up0.0376073561
GSE37065Up0.0651328203
GSE28863_A1Down-0.0884884786
GSE28863_A2Up0.0611208384
GSE28863_A3Up0.2154903489
GSE28863_A4Up0.0545537304
GSE48662Up0.0197280572

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-101-3pMIMAT0000099MIRT000378Luciferase reporter assay//Reporter assayFunctional MTI14697198
hsa-miR-101-3pMIMAT0000099MIRT000378Western blotNon-Functional MTI19008416
hsa-miR-101-3pMIMAT0000099MIRT000378Reporter assayFunctional MTI21654684
hsa-miR-34a-5pMIMAT0000255MIRT000980Luciferase reporter assay//Western blotFunctional MTI18504438
hsa-miR-34a-5pMIMAT0000255MIRT000980qRT-PCR//Western blot//Luciferase reporter assayFunctional MTI18505919
hsa-miR-34a-5pMIMAT0000255MIRT000980Luciferase reporter assayFunctional MTI19461653
hsa-miR-34a-5pMIMAT0000255MIRT000980Luciferase reporter assayNon-Functional MTI17297439
hsa-miR-34a-5pMIMAT0000255MIRT000980Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-34a-5pMIMAT0000255MIRT000980Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22662276
hsa-miR-34c-5pMIMAT0000686MIRT006225Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-34b-3pMIMAT0004676MIRT006224Luciferase reporter assay//Western blotFunctional MTI22020437
hsa-miR-29a-3pMIMAT0000086MIRT006135Reporter assayFunctional MTI21654684
hsa-miR-202-3pMIMAT0002811MIRT016613Reporter assayFunctional MTI21654684
hsa-miR-29c-3pMIMAT0000681MIRT020415Reporter assayFunctional MTI21654684
hsa-miR-29b-3pMIMAT0000100MIRT027239Reporter assayFunctional MTI21654684
hsa-miR-19b-3pMIMAT0000074MIRT031210Reporter assayFunctional MTI21654684
hsa-miR-19a-3pMIMAT0000073MIRT031308Reporter assayFunctional MTI14697198
hsa-let-7e-5pMIMAT0000066MIRT032100Reporter assayFunctional MTI21654684
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-101-3pMIMAT00000991hsa-miR-10114697198
hsa-miR-101-3pMIMAT00000992hsa-miR-10114697198
hsa-miR-34a-5pMIMAT00002552hsa-miR-34a{Western blot}{overexpression by miRNA mimics transfection}18504438
hsa-miR-34a-5pMIMAT00002551hsa-miR-34a{Western blot}{overexpression by miRNA mimics transfection}18504438
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24045179Although our data indicate that neuroblastomas sensitive to LEE011 were more likely to contain genomic amplification of MYCN (P = 0
24041229The interaction between FAK, MYCN, p53 and Mdm2 in neuroblastoma
24041229This review focuses on the individual protein tyrosine kinase, focal adhesion kinase (FAK) and its interaction with the transcription factors, MYCN, p53, and Mdm2, and how their interactions modulate the growth and malignancy of neuroblastomas
21258399The identification of MITF-binding sites and gene-regulatory networks establish a framework for understanding oncogenic basic helix-loop-helix factors such as N-myc or TFE3 in other cancers
20348948Using microarray analysis we identified a large cohort of novel TBX2-repressed target genes including the breast tumour suppressor NDRG1 (N-myc downregulated gene 1)
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