HCSGD entry for MXI1
1. General information
| Official gene symbol | MXI1 |
|---|---|
| Entrez ID | 4601 |
| Gene full name | MAX interactor 1, dimerization protein |
| Other gene symbols | MAD2 MXD2 MXI bHLHc11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0042994 | Cytoplasmic sequestering of transcription factor | TAS | biological_process |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0045683979 | 0.7545132214 | 0.1782794074 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4959657400 |
| GSE13712_SHEAR | Down | -0.5593836844 |
| GSE13712_STATIC | Down | -0.3591161716 |
| GSE19018 | Up | 3.0208634481 |
| GSE19899_A1 | Up | 0.9558567185 |
| GSE19899_A2 | Up | 0.9184377974 |
| PubMed_21979375_A1 | Up | 0.4525980153 |
| PubMed_21979375_A2 | Up | 2.0409181291 |
| GSE35957 | Down | -0.2053094272 |
| GSE36640 | Up | 0.6859875979 |
| GSE54402 | Down | -0.1791420865 |
| GSE9593 | Up | 0.7044750751 |
| GSE43922 | Up | 0.2360549882 |
| GSE24585 | Down | -0.0478635620 |
| GSE37065 | Up | 0.1359626930 |
| GSE28863_A1 | Up | 0.0202531062 |
| GSE28863_A2 | Up | 0.4621946796 |
| GSE28863_A3 | Down | -0.0695468173 |
| GSE28863_A4 | Down | -0.1411791336 |
| GSE48662 | Up | 0.6733268250 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017857 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020453 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020453 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024480 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026461 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029559 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039065 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040089 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047907 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
