HCSGD entry for MVD
1. General information
| Official gene symbol | MVD |
|---|---|
| Entrez ID | 4597 |
| Gene full name | mevalonate (diphospho) decarboxylase |
| Other gene symbols | FP17780 MPD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004163 | Diphosphomevalonate decarboxylase activity | IDA IEA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA NAS TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0008299 | Isoprenoid biosynthetic process | IDA IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030544 | Hsp70 protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3048231602 | 0.4505336499 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0132275363 |
| GSE13712_SHEAR | Down | -0.5807580121 |
| GSE13712_STATIC | Down | -0.3168074104 |
| GSE19018 | Up | 0.1512135584 |
| GSE19899_A1 | Down | -0.1444758921 |
| GSE19899_A2 | Up | 0.7463810511 |
| PubMed_21979375_A1 | Down | -0.1800045269 |
| PubMed_21979375_A2 | Down | -0.5650702902 |
| GSE35957 | Up | 0.0876020730 |
| GSE36640 | Up | 0.1609697575 |
| GSE54402 | Up | 0.0840201748 |
| GSE9593 | Up | 0.1407695281 |
| GSE43922 | Up | 0.1477162133 |
| GSE24585 | Down | -0.0497594127 |
| GSE37065 | Down | -0.1384102739 |
| GSE28863_A1 | Down | -0.0594153081 |
| GSE28863_A2 | Down | -0.0054914909 |
| GSE28863_A3 | Up | 0.2843283709 |
| GSE28863_A4 | Up | 0.1028848852 |
| GSE48662 | Up | 0.7499499790 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022326 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029055 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12646231 | Mevalonate pyrophosphate decarboxylase (MPD) was identified as one of the mortalin binding partners |
| 12646231 | MPD is known to furnish prenyl groups required for prenylation, protein modification that is essential for the activity of many proteins including p21(Ras) (Ras) |
| 12646231 | These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras |
| 7440633 | Our studies show that as cells traverse the replicative lifespan (from 10 to 75 mean population doublings (MPD); total lifespan congruent to 95 MPD), no rapid and exponential increase occurs in the accumulation of mutations measured by the frequencies of Thgr(thioguanine resistance) and Dipr (diphtheria toxin resistance) mutants |
| 7440633 | On the contrary, repeated mutagen treatment (12 times with EMS) prolonged the lifespan of one replicative culture (110 MPD versus 94--98 MPD) |
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