HCSGD entry for MTR
1. General information
| Official gene symbol | MTR |
|---|---|
| Entrez ID | 4548 |
| Gene full name | 5-methyltetrahydrofolate-homocysteine methyltransferase |
| Other gene symbols | MS cblG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008705 | Methionine synthase activity | IEA | molecular_function |
| GO:0008898 | Homocysteine S-methyltransferase activity | IEA | molecular_function |
| GO:0009235 | Cobalamin metabolic process | TAS | biological_process |
| GO:0031419 | Cobalamin binding | IEA | molecular_function |
| GO:0032259 | Methylation | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042558 | Pteridine-containing compound metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3588914213 | 0.0159120892 | 0.9999902473 | 0.2461419355 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9033805697 |
| GSE13712_SHEAR | Down | -0.2333532639 |
| GSE13712_STATIC | Up | 0.0092455783 |
| GSE19018 | Down | -0.0625873642 |
| GSE19899_A1 | Down | -0.7176597702 |
| GSE19899_A2 | Down | -1.2239020261 |
| PubMed_21979375_A1 | Down | -1.0141061262 |
| PubMed_21979375_A2 | Down | -0.7255657669 |
| GSE35957 | Up | 0.0443521084 |
| GSE36640 | Down | -0.7286898437 |
| GSE54402 | Down | -0.1250784672 |
| GSE9593 | Down | -0.1099537243 |
| GSE43922 | Down | -0.5778813363 |
| GSE24585 | Down | -0.0142891229 |
| GSE37065 | Down | -0.0068859351 |
| GSE28863_A1 | Up | 1.1341802473 |
| GSE28863_A2 | Up | 2.0134189319 |
| GSE28863_A3 | Up | 0.2247495987 |
| GSE28863_A4 | Down | -0.2830630974 |
| GSE48662 | Up | 0.1057472310 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Cyanocobalamin | DB00115 | NUTR00004 | APRD00326 | EXPT00965 |
| Tetrahydrofolic acid | DB00116 | NUTR00056 |
| Hydroxocobalamin | DB00200 | APRD01022 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041354 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042208 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044357 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047589 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26885754 | The effect of exercise on wound healing in aging tendon was tested using a rat moderate treadmill running (MTR) model |
| 26885754 | The rats were divided into an MTR group that ran on a treadmill for 4 weeks and a control group that remained in cages |
| 26885754 | After MTR, a window defect was created in the patellar tendons of all rats and wound healing was analyzed |
| 26885754 | We found that MTR accelerated wound healing by promoting quicker closure of wounds, improving the organization of collagen fibers, and decreasing senescent cells in the wounded tendons when compared to the cage control |
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