HCSGD entry for MTHFD1
1. General information
| Official gene symbol | MTHFD1 |
|---|---|
| Entrez ID | 4522 |
| Gene full name | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| Other gene symbols | MTHFC MTHFD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000105 | Histidine biosynthetic process | IEA | biological_process |
| GO:0004329 | Formate-tetrahydrofolate ligase activity | IBA IEA TAS | molecular_function |
| GO:0004477 | Methenyltetrahydrofolate cyclohydrolase activity | IBA TAS | molecular_function |
| GO:0004486 | Methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | TAS | molecular_function |
| GO:0004488 | Methylenetetrahydrofolate dehydrogenase (NADP+) activity | IBA IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IBA TAS | cellular_component |
| GO:0006164 | Purine nucleotide biosynthetic process | IEA | biological_process |
| GO:0006730 | One-carbon metabolic process | IBA | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0009086 | Methionine biosynthetic process | IEA | biological_process |
| GO:0009396 | Folic acid-containing compound biosynthetic process | IEA | biological_process |
| GO:0035999 | Tetrahydrofolate interconversion | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046655 | Folic acid metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9401097793 | 0.0338889252 | 0.9999902473 | 0.3473277929 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0279260644 |
| GSE13712_SHEAR | Down | -0.1668618985 |
| GSE13712_STATIC | Down | -0.0034718633 |
| GSE19018 | Down | -0.3230511517 |
| GSE19899_A1 | Down | -0.6001071102 |
| GSE19899_A2 | Up | 0.0888942961 |
| PubMed_21979375_A1 | Up | 0.7367601417 |
| PubMed_21979375_A2 | Down | -0.3500264061 |
| GSE35957 | Down | -0.5246412927 |
| GSE36640 | Down | -0.9666799135 |
| GSE54402 | Up | 0.0165091252 |
| GSE9593 | Down | -0.0103265918 |
| GSE43922 | Down | -0.2152471159 |
| GSE24585 | Down | -0.4576055186 |
| GSE37065 | Down | -0.1183532857 |
| GSE28863_A1 | Up | 0.1537454093 |
| GSE28863_A2 | Up | 0.2356595322 |
| GSE28863_A3 | Down | -0.2824352072 |
| GSE28863_A4 | Up | 0.1348249097 |
| GSE48662 | Down | -0.7241282895 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tetrahydrofolic acid | DB00116 | NUTR00056 |
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| LY374571 | DB02358 | EXPT01992 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
| LY249543 | DB04322 | EXPT01990 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016506 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037267 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037507 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043098 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044374 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050788 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052561 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
