HCSGD entry for MT3

1. General information

Official gene symbolMT3
Entrez ID4504
Gene full namemetallothionein 3
Other gene symbolsGIF GIFB GRIF ZnMT3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIDAbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0005507Copper ion bindingIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006112Energy reserve metabolic processISSbiological_process
GO:0006707Cholesterol catabolic processISSbiological_process
GO:0006829Zinc ion transportISSbiological_process
GO:0006875Cellular metal ion homeostasisNAS TASbiological_process
GO:0006882Cellular zinc ion homeostasisISSbiological_process
GO:0008021Synaptic vesicleISScellular_component
GO:0008144Drug bindingIDAmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0010507Negative regulation of autophagyISSbiological_process
GO:0010628Positive regulation of gene expressionIDA ISSbiological_process
GO:0010940Positive regulation of necrotic cell deathIDAbiological_process
GO:0010942Positive regulation of cell deathIDA ISSbiological_process
GO:0014002Astrocyte developmentISSbiological_process
GO:0016209Antioxidant activityNASmolecular_function
GO:0016234Inclusion bodyIDAcellular_component
GO:0016570Histone modificationIMPbiological_process
GO:0019430Removal of superoxide radicalsIDAbiological_process
GO:0030295Protein kinase activator activityIDAmolecular_function
GO:0030308Negative regulation of cell growthIDA IMP TASbiological_process
GO:0030517Negative regulation of axon extensionIDAbiological_process
GO:0030949Positive regulation of vascular endothelial growth factor receptor signaling pathwayIDAbiological_process
GO:0032095Regulation of response to foodISSbiological_process
GO:0032148Activation of protein kinase B activityIDAbiological_process
GO:0033210Leptin-mediated signaling pathwayISSbiological_process
GO:0034599Cellular response to oxidative stressIEPbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0036091Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stressIDAbiological_process
GO:0043027Cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDAmolecular_function
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043085Positive regulation of catalytic activityISSbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAbiological_process
GO:0043491Protein kinase B signalingIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0044242Cellular lipid catabolic processISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0046870Cadmium ion bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050821Protein stabilizationIDAbiological_process
GO:0051354Negative regulation of oxidoreductase activityIDAbiological_process
GO:0055069Zinc ion homeostasisIDAbiological_process
GO:0055073Cadmium ion homeostasisIDAbiological_process
GO:0060049Regulation of protein glycosylationISSbiological_process
GO:0060547Negative regulation of necrotic cell deathIDA ISSbiological_process
GO:0070371ERK1 and ERK2 cascadeIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA ISSbiological_process
GO:0071276Cellular response to cadmium ionIDAbiological_process
GO:0071456Cellular response to hypoxiaIEPbiological_process
GO:0071732Cellular response to nitric oxideIDAbiological_process
GO:0097214Positive regulation of lysosomal membrane permeabilityISSbiological_process
GO:2000117Negative regulation of cysteine-type endopeptidase activityIDAbiological_process
GO:2000376Positive regulation of oxygen metabolic processISSbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07414218300.91160290260.57822115561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3012379088
GSE13712_SHEARUp0.0100568133
GSE13712_STATICUp0.1616143576
GSE19018Up0.3611790003
GSE19899_A1Up0.1350191055
GSE19899_A2Up0.2786714952
PubMed_21979375_A1Down-0.1764407192
PubMed_21979375_A2Up0.1688204851
GSE35957Up0.0806983038
GSE36640Up0.0253243014
GSE54402Up2.0928110522
GSE9593Down-0.0493518677
GSE43922Up0.0931964147
GSE24585Up0.0239241892
GSE37065Down-0.0733260533
GSE28863_A1Up0.0100169155
GSE28863_A2Down-0.1201906930
GSE28863_A3Up0.3261444498
GSE28863_A4Up0.1446034693
GSE48662Up0.3467833850

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.