HCSGD entry for MT1G
1. General information
| Official gene symbol | MT1G |
|---|---|
| Entrez ID | 4495 |
| Gene full name | metallothionein 1G |
| Other gene symbols | MT1 MT1K |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0030224 | Monocyte differentiation | NAS | biological_process |
| GO:0035924 | Cellular response to vascular endothelial growth factor stimulus | IEP | biological_process |
| GO:0042117 | Monocyte activation | NAS | biological_process |
| GO:0045926 | Negative regulation of growth | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0071276 | Cellular response to cadmium ion | IEP | biological_process |
| GO:0071280 | Cellular response to copper ion | IEP | biological_process |
| GO:0071294 | Cellular response to zinc ion | IDA IEP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0111273280 | 0.9820999772 | 0.2667417122 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4315633120 |
| GSE13712_SHEAR | Up | 0.9365812109 |
| GSE13712_STATIC | Up | 0.3889740749 |
| GSE19018 | Up | 0.5451791809 |
| GSE19899_A1 | Up | 0.1883529305 |
| GSE19899_A2 | Up | 0.2915669433 |
| PubMed_21979375_A1 | Up | 0.2597762160 |
| PubMed_21979375_A2 | Up | 0.1355467784 |
| GSE35957 | Down | -0.3929577402 |
| GSE36640 | Up | 0.2217976756 |
| GSE54402 | Up | 0.5981790454 |
| GSE9593 | Up | 0.2887250907 |
| GSE43922 | Up | 0.0240469063 |
| GSE24585 | Down | -0.0125181228 |
| GSE37065 | Up | 0.3882275470 |
| GSE28863_A1 | Down | -0.1594131782 |
| GSE28863_A2 | Up | 0.0651352609 |
| GSE28863_A3 | Up | 0.6500410279 |
| GSE28863_A4 | Up | 0.0959970439 |
| GSE48662 | Up | 0.2187232813 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20705054 | Moreover, MT-1G, which is induced by SM22alpha overexpression, was involved in the activation of the p16(INK4a)/pRB pathway, which led to a growth arrest state and promoted cellular senescence caused by damaging agents |
| 20705054 | Our findings provide the first demonstration that SM22alpha modulates cellular senescence caused by damaging agents via regulation of the p16(INK4a)/pRB pathway in HepG2 cells and that these effects of SM22alpha are partially mediated by MT-1G |
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