HCSGD entry for MSRA
1. General information
| Official gene symbol | MSRA |
|---|---|
| Entrez ID | 4482 |
| Gene full name | methionine sulfoxide reductase A |
| Other gene symbols | PMSR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006555 | Methionine metabolic process | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0008113 | Peptide-methionine (S)-S-oxide reductase activity | IEA | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030091 | Protein repair | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9236963489 | 0.1882024201 | 0.9999902473 | 0.8404607906 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2157193330 |
| GSE13712_SHEAR | Down | -0.1604786537 |
| GSE13712_STATIC | Down | -0.2021207643 |
| GSE19018 | Up | 0.1314104955 |
| GSE19899_A1 | Down | -0.3249971497 |
| GSE19899_A2 | Down | -0.1601283315 |
| PubMed_21979375_A1 | Down | -0.7022743672 |
| PubMed_21979375_A2 | Down | -0.4055287787 |
| GSE35957 | Up | 0.1310756420 |
| GSE36640 | Down | -0.0725593286 |
| GSE54402 | Up | 0.0595325803 |
| GSE9593 | Up | 0.0273203506 |
| GSE43922 | Down | -0.1279983084 |
| GSE24585 | Up | 0.0275094611 |
| GSE37065 | Down | -0.0026773357 |
| GSE28863_A1 | Up | 0.1009846399 |
| GSE28863_A2 | Up | 0.1352611026 |
| GSE28863_A3 | Up | 0.0726139936 |
| GSE28863_A4 | Down | -0.0578558207 |
| GSE48662 | Down | -0.4571001401 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1,4-Dithiothreitol | DB04447 | EXPT01291 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022647 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22086179 | MsrA is an oxidoreductase that catalyzes the stereospecific reduction of methionine-S-sulfoxide to methionine |
| 22086179 | Although MsrA is well-characterized as an antioxidant and has been implicated in the aging process and cellular senescence, its roles in cell proliferation are poorly understood |
| 22086179 | Here, we report a critical role of MsrA in normal cell proliferation and describe the regulation mechanism of cell growth by this protein |
| 22086179 | Down-regulation of MsrA inhibited cell proliferation, but MsrA overexpression did not promote it |
| 22086179 | MsrA deficiency led to an increase in p21, a major cyclin-dependent kinase inhibitor, thereby causing cell cycle arrest at the G(2)/M stage |
| 22086179 | While protein levels of p53 were not altered upon MsrA deficiency, its acetylation level was significantly elevated, which subsequently activated p21 transcription |
| 22086179 | The data suggest that MsrA is a regulator of cell growth that mediates the p53-p21 pathway |
| 18977241 | Telomere lengths were calculated for 190 (82 men, 108 women) participants aged 79 years and associations with 384 SNPs, from 141 oxidative stress genes, identified 9 significant SNPS, of which those from 5 genes (GSTZ1, MSRA, NDUFA3, NDUFA8, VIM) had robust associations with physical aging biomarkers, respiratory function or grip strength |
| 18977241 | Replication of associations in a sample of 318 (120 males, 198 females) participants aged 50 years confirmed significant associations for two of the five SNPs (MSRA rs4841322, p=0 |
| 15680234 | Protein-bound methionine sulfoxide diastereoisomers S and R are repaired by the combined action of the enzymes MsrA and MsrB that are subsequently regenerated by thioredoxin/thioredoxin reductase |
| 15680234 | In a previous study, we reported that peptide methionine sulfoxide reductase activity as well as gene and protein expression of MsrA are decreased in various organs as a function of age |
| 15680234 | More recently, we have shown that gene expression of both MsrA and MsrB2 (Cbs-1) is decreased during replicative senescence of WI-38 fibroblasts, and this decline is associated with an alteration in catalytic activity and the accumulation of oxidized protein |
| 14759519 | The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts |
| 14759519 | In contrast to other oxidative modifications of amino acids, methionine sulfoxide can be enzymatically reduced back to methionine in proteins by the peptide methionine sulfoxide reductase system, composed of MsrA and MsrB |
| 14759519 | The expression of MsrA and one member of the MsrB family, hCBS-1, was analyzed during replicative senescence of WI-38 human fibroblasts |
| 14759519 | These results suggest that downregulation of MsrA and hCBS-1 can alter the ability of senescent cells to cope with oxidative stress, hence contributing to the age-related accumulation of oxidative damage |
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