HCSGD entry for ASPH

1. General information

Official gene symbolASPH
Entrez ID444
Gene full nameaspartate beta-hydroxylase
Other gene symbolsAAH BAH CASQ2BP1 HAAH JCTN junctin
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004597Peptide-aspartate beta-dioxygenase activityIEAmolecular_function
GO:0005198Structural molecule activityTASmolecular_function
GO:0005509Calcium ion bindingIDA NASmolecular_function
GO:0005513Detection of calcium ionTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumTAScellular_component
GO:0005789Endoplasmic reticulum membraneNAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006936Muscle contractionTASbiological_process
GO:0007389Pattern specification processIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0008307Structural constituent of muscleTASmolecular_function
GO:0009055Electron carrier activityTASmolecular_function
GO:0010524Positive regulation of calcium ion transport into cytosolIDAbiological_process
GO:0010649Regulation of cell communication by electrical couplingTASbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumTASbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionISS TASbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0031585Regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityIDAbiological_process
GO:0031647Regulation of protein stabilityIEAbiological_process
GO:0032237Activation of store-operated calcium channel activityIDAbiological_process
GO:0032541Cortical endoplasmic reticulumIDAcellular_component
GO:0033017Sarcoplasmic reticulum membraneTAScellular_component
GO:0033018Sarcoplasmic reticulum lumenTAScellular_component
GO:0033198Response to ATPIDAbiological_process
GO:0034704Calcium channel complexTAScellular_component
GO:0035108Limb morphogenesisIEAbiological_process
GO:0042264Peptidyl-aspartic acid hydroxylationIEAbiological_process
GO:0044325Ion channel bindingTASmolecular_function
GO:0045862Positive regulation of proteolysisIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityTASbiological_process
GO:0060316Positive regulation of ryanodine-sensitive calcium-release channel activityTASbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0070588Calcium ion transmembrane transportIDAbiological_process
GO:0071277Cellular response to calcium ionIDAbiological_process
GO:0090316Positive regulation of intracellular protein transportIDAbiological_process
GO:0097202Activation of cysteine-type endopeptidase activityIDAbiological_process
GO:1901879Regulation of protein depolymerizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34703400710.33221954710.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0386828743
GSE13712_SHEARUp0.1020806960
GSE13712_STATICUp0.3295100825
GSE19018Up0.4012276254
GSE19899_A1Down-0.1103214718
GSE19899_A2Down-0.2513376321
PubMed_21979375_A1Down-0.5073114947
PubMed_21979375_A2Down-0.0567401628
GSE35957Up0.0670498031
GSE36640Up0.2154879921
GSE54402Down-0.2284926474
GSE9593Up0.6317890437
GSE43922Down-0.0799579533
GSE24585Down-0.6520331820
GSE37065Up0.0604475726
GSE28863_A1Up0.2355222438
GSE28863_A2Up0.1189347574
GSE28863_A3Up0.0601365027
GSE28863_A4Down-0.1816472372
GSE48662Up0.2910945836

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Aspartic AcidDB00128 NUTR00016 | EXPT01823

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020908ProteomicsFunctional MTI (Weak)18668040
hsa-miR-215-5pMIMAT0000272MIRT024363MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026731MicroarrayFunctional MTI (Weak)19074876
hsa-miR-16-5pMIMAT0000069MIRT031802MicroarrayFunctional MTI (Weak)21199864
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26683595ASPH knockdown or knockout was achieved by short hairpin RNAs or the CRISPR/Cas9 system, respectively, whereas enzymatic inhibition was rendered by a potent second-generation small molecule inhibitor of ASPH
26683595Inhibition of ASPH expression and enzymatic activity significantly reduced cell proliferation and colony formation but induced tumor cell senescence
26683595Following inhibition of ASPH activity, phosphorylation of glycogen synthase kinase 3beta and p16 expression were increased to promote senescence, whereas cyclin D1 and proliferating cell nuclear antigen were decreased to reduce cell proliferation
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