HCSGD entry for MPO

1. General information

Official gene symbolMPO
Entrez ID4353
Gene full namemyeloperoxidase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001878Response to yeastIEAbiological_process
GO:0002149Hypochlorous acid biosynthetic processIEAbiological_process
GO:0002679Respiratory burst involved in defense responseIEAbiological_process
GO:0003682Chromatin bindingTASmolecular_function
GO:0004601Peroxidase activityIDA IEAmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusTAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005764LysosomeTAScellular_component
GO:0006952Defense responseTASbiological_process
GO:0006979Response to oxidative stressIEA TASbiological_process
GO:0007568AgingIEAbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0019430Removal of superoxide radicalsIEAbiological_process
GO:0020037Heme bindingIEAmolecular_function
GO:0030141Secretory granuleIDAcellular_component
GO:0032094Response to foodIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0034374Low-density lipoprotein particle remodelingIDAbiological_process
GO:0042582Azurophil granuleIDAcellular_component
GO:0042744Hydrogen peroxide catabolic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050832Defense response to fungusIEAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53443506710.92062156830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1094569410
GSE13712_SHEARUp0.0124522665
GSE13712_STATICUp0.0902002821
GSE19018Up0.0036052829
GSE19899_A1Down-0.0327398243
GSE19899_A2Up0.1307135908
PubMed_21979375_A1Up0.2152165094
PubMed_21979375_A2Up0.1489171555
GSE35957Up0.0086058109
GSE36640Up0.1082879976
GSE54402Down-0.0211156363
GSE9593Down-0.0876663068
GSE43922Up0.0632098577
GSE24585Up0.3522853190
GSE37065Down-0.0605190686
GSE28863_A1Down-0.0231436068
GSE28863_A2Up0.0980108373
GSE28863_A3Up0.2955013446
GSE28863_A4Up0.0071310055
GSE48662Down-0.0127443428

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1630733CHEMBL24398P05164
CHEMBL406029CHEMBL24398P05164
CHEMBL275628CHEMBL24398P05164
CHEMBL1630743CHEMBL24398P05164
CHEMBL271973CHEMBL24398P05164
CHEMBL1630734CHEMBL24398P05164
CHEMBL1630733CHEMBL24398P05164
CHEMBL1630743CHEMBL24398P05164
CHEMBL259242CHEMBL24398P05164
CHEMBL1630735CHEMBL24398P05164
CHEMBL1630736CHEMBL24398P05164
CHEMBL1630738CHEMBL24398P05164
CHEMBL270922CHEMBL24398P05164
CHEMBL361949CHEMBL24398P05164
CHEMBL1630732CHEMBL24398P05164
CHEMBL1630735CHEMBL24398P05164
CHEMBL1630741CHEMBL24398P05164
CHEMBL1630722CHEMBL24398P05164
CHEMBL1630723CHEMBL24398P05164
CHEMBL1630737CHEMBL24398P05164
CHEMBL1630727CHEMBL24398P05164
CHEMBL1630730CHEMBL24398P05164
CHEMBL1630741CHEMBL24398P05164
CHEMBL1630729CHEMBL24398P05164
CHEMBL271126CHEMBL24398P05164
CHEMBL1630740CHEMBL24398P05164
CHEMBL429437CHEMBL24398P05164
CHEMBL275628CHEMBL24398P05164
CHEMBL1630728CHEMBL24398P05164
CHEMBL1630736CHEMBL24398P05164
CHEMBL1630739CHEMBL24398P05164
CHEMBL1630734CHEMBL24398P05164
CHEMBL1630725CHEMBL24398P05164
CHEMBL1630737CHEMBL24398P05164
CHEMBL1630731CHEMBL24398P05164
CHEMBL1630732CHEMBL24398P05164
CHEMBL1630729CHEMBL24398P05164
CHEMBL1630742CHEMBL24398P05164
CHEMBL259241CHEMBL24398P05164
CHEMBL1630728CHEMBL24398P05164
CHEMBL1630739CHEMBL24398P05164
CHEMBL361949CHEMBL24398P05164
CHEMBL1630727CHEMBL24398P05164
CHEMBL1630726CHEMBL24398P05164
CHEMBL1630726CHEMBL24398P05164
CHEMBL1630742CHEMBL24398P05164
CHEMBL23588CHEMBL24398P05164
CHEMBL1630724CHEMBL24398P05164
CHEMBL1630730CHEMBL24398P05164
CHEMBL1630738CHEMBL24398P05164
CHEMBL1630731CHEMBL24398P05164
CHEMBL1630725CHEMBL24398P05164
CHEMBL1630740CHEMBL24398P05164
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  • Drugs

Name

Drug

Accession number

L-CarnitineDB00583 APRD01070
MelatoninDB01065 APRD00742 | DB08189

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26474698Myeloperoxidase (MPO)-derived product hypochlorous acid (HOCl) is able to induce cellular senescence and MPO is also expressed in endothelial cells besides the well-recognized immune cells
26474698This study aims to clarify the association of endothelium-derived MPO with endothelial senescence in hyperlipidemia
26474698The rats were fed with high-fat diet for 8 weeks to establish a hyperlipidemic model, which showed an increase in plasma lipids, endothelium-derived MPO expression, endothelial senescence and endothelial dysfunction concomitant with a reduction in glycogen synthase kinase 3 beta (GSK-3beta) activity and phosphorylated beta-catenin (p-beta-catenin) level as well as an increase in beta-catenin and p53 levels within the endothelium
26474698Consistent with the finding in vivo, ox-LDL-induced MPO expression and HUVECs senescence, accompanied by a decrease in GSK-3beta activity and p-beta-catenin level as well as an increase in HOCl content, beta-catenin and p53 levels; these phenomena were attenuated by MPO inhibitor
26474698Based on these observations, we conclude that endothelium-derived MPO is upregulated in hyperlipidemic rats, which may contribute to the accelerated vascular endothelial senescence through a mechanism involving the beta-catenin/p53 pathway
26360782Furthermore, CD34(+) cell B2R expression in patients with DM was inversely correlated with plasma myeloperoxidase concentrations
22963552This includes specific spin traps like alpha-phenyl-N-tert-butyl nitrone, a catalytic antioxidant (ECSOD mimetic), porphyrins (AEOL 10150 and AEOL 10113), and a superoxide dismutase mimetic M40419, lipid peroxidation and protein carbonylation blockers/inhibitors, such as edaravone and lazaroids/tirilazad, myeloperoxidase inhibitors, as well as specialized pro-resolving mediators/inflammatory resolving lipid mediators, omega-3 fatty acids, vitamin D, and hydrogen sulfide
10197787There were no differences in the baseline levels of malondialdehyde or myeloperoxidase activity (indicators of lipid peroxidation and neutrophil infiltration, respectively) between young and aged mice
10197787Although intestinal I/R caused a significant increase in malondialdehyde levels and myeloperoxidase activity in aged mice, similar increases were also observed in young mice
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