HCSGD entry for MN1
1. General information
| Official gene symbol | MN1 |
|---|---|
| Entrez ID | 4330 |
| Gene full name | meningioma (disrupted in balanced translocation) 1 |
| Other gene symbols | MGCR MGCR1 MGCR1-PEN dJ353E16.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001957 | Intramembranous ossification | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0008150 | Biological_process | ND | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8714155997 | 0.0013698378 | 0.9999902473 | 0.0715648221 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -2.2629816024 |
| GSE13712_SHEAR | Down | -1.3863061288 |
| GSE13712_STATIC | Down | -0.8182918753 |
| GSE19018 | Down | -0.6837402694 |
| GSE19899_A1 | Down | -0.3118706690 |
| GSE19899_A2 | Down | -2.7970320254 |
| PubMed_21979375_A1 | Down | -0.1474842652 |
| PubMed_21979375_A2 | Down | -0.2956451828 |
| GSE35957 | Down | -1.1201954947 |
| GSE36640 | Down | -1.1472180877 |
| GSE54402 | Down | -1.3475635442 |
| GSE9593 | Down | -0.1533537746 |
| GSE43922 | Up | 0.0642874478 |
| GSE24585 | Down | -0.0097562022 |
| GSE37065 | Up | 0.5091655675 |
| GSE28863_A1 | Up | 0.6153156266 |
| GSE28863_A2 | Down | -0.0736855906 |
| GSE28863_A3 | Up | 0.6403556146 |
| GSE28863_A4 | Down | -0.1373401490 |
| GSE48662 | Down | -0.3610648996 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018049 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021439 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23904845 | CASE REPORT: A 72-year-old Caucasian woman with a history of multiple cancers (metachronous bilateral breast cancer, meningioma, clear cell renal cell carcinoma, uterine fibromatosis and intestinal adenomatous polyposis), came to our attention with a nodular lesion on her back |
| 17962031 | To investigate merlin function in an authentic target cell type for NF2 tumor formation, we established primary cultures from genetically-matched meningioma and normal arachnoidal tissues |
| 17962031 | Merlin-deficient meningioma cells displayed cytoskeletal and cell contact defects, altered cell morphology and growth properties, most notably cell senescence, implicating the activation of senescence pathways in limiting benign meningioma growth |
| 17962031 | Merlin suppression by RNAi in arachnoidal cells replicated merlin-deficient meningioma features, thus establishing these cell systems as disease-relevant models for studying NF2 tumorigenesis |
| 15965488 | Meningioma represents the most common intracranial tumor, but well-characterized cell lines derived from benign meningiomas are not available |
| 15965488 | We have developed a meningioma cell line by retrovirally transducing primary cells derived from a human WHO grade I meningothelial meningioma with the human telomerase reverse transcriptase (hTERT) gene, which enables bypassing cellular senescence |
| 15965488 | One clone, designated Ben-Men-1, was characterized in more detail, and exhibited typical cytological, immunocytochemical, ultrastructural and genetical features of meningioma, including whorl formation, expression of epithelial membrane antigen, desmosomes and interdigitating cell processes, as well as -22q |
| 15965488 | Following subdural transplantation into nude mice, tumor tissue with typical histological features of meningothelial meningioma was found |
| 15965488 | We conclude that Ben-Men-1 represents an immortalized yet differentiated cell line useful for biological and therapeutical studies on meningioma |
| 11066050 | CONCLUSIONS: The results indicate that telomerase activation may be a critical step in the pathogenesis of malignant or atypical meningioma |
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