HCSGD entry for MMP17
1. General information
| Official gene symbol | MMP17 |
|---|---|
| Entrez ID | 4326 |
| Gene full name | matrix metallopeptidase 17 (membrane-inserted) |
| Other gene symbols | MT4-MMP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3604933741 | 0.7637456176 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0050484905 |
| GSE13712_SHEAR | Up | 0.0857216319 |
| GSE13712_STATIC | Up | 0.5374633235 |
| GSE19018 | Up | 0.0871556337 |
| GSE19899_A1 | Down | -0.1821820193 |
| GSE19899_A2 | Up | 0.0439787269 |
| PubMed_21979375_A1 | Down | -0.0756281009 |
| PubMed_21979375_A2 | Up | 0.1438057267 |
| GSE35957 | Up | 0.0368158386 |
| GSE36640 | Down | -0.1619531005 |
| GSE54402 | Down | -0.0729977815 |
| GSE9593 | Down | -0.1038974614 |
| GSE43922 | Up | 0.0541753233 |
| GSE24585 | Up | 0.0381338234 |
| GSE37065 | Down | -0.0326080571 |
| GSE28863_A1 | Down | -0.1000663354 |
| GSE28863_A2 | Down | -0.0148007406 |
| GSE28863_A3 | Up | 0.3054786671 |
| GSE28863_A4 | Up | 0.0519549209 |
| GSE48662 | Up | 0.6763996399 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018145 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
