HCSGD entry for MMP15
1. General information
| Official gene symbol | MMP15 |
|---|---|
| Entrez ID | 4324 |
| Gene full name | matrix metallopeptidase 15 (membrane-inserted) |
| Other gene symbols | MT2-MMP MTMMP2 SMCP-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | TAS | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IEA | cellular_component |
| GO:0032355 | Response to estradiol | IEA | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3077187683 | 0.7140994453 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0689649671 |
| GSE13712_SHEAR | Down | -0.5963522346 |
| GSE13712_STATIC | Down | -0.1290415285 |
| GSE19018 | Up | 0.0839116377 |
| GSE19899_A1 | Up | 0.0055912906 |
| GSE19899_A2 | Up | 0.1832794511 |
| PubMed_21979375_A1 | Up | 0.0128370226 |
| PubMed_21979375_A2 | Up | 0.0169316461 |
| GSE35957 | Up | 0.2594546148 |
| GSE36640 | Up | 0.2142519404 |
| GSE54402 | Up | 0.0391290185 |
| GSE9593 | Up | 0.1694578476 |
| GSE43922 | Up | 0.1755305159 |
| GSE24585 | Down | -0.5423745111 |
| GSE37065 | Up | 0.2303850768 |
| GSE28863_A1 | Down | -0.1259723408 |
| GSE28863_A2 | Down | -0.0138182424 |
| GSE28863_A3 | Up | 0.4005690873 |
| GSE28863_A4 | Up | 0.1559121120 |
| GSE48662 | Up | 0.1998096432 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT005383 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21305051 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT005384 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21305051 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
