HCSGD entry for MMP12

1. General information

Official gene symbolMMP12
Entrez ID4321
Gene full namematrix metallopeptidase 12 (macrophage elastase)
Other gene symbolsHME ME MME MMP-12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004175Endopeptidase activityTASmolecular_function
GO:0004222Metalloendopeptidase activityTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIDAbiological_process
GO:0060054Positive regulation of epithelial cell proliferation involved in wound healingIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00009656550.20795831090.02777526880.8832194973

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.6419371086
GSE13712_SHEARUp0.0877882437
GSE13712_STATICDown-0.1031660259
GSE19018Up0.0287532719
GSE19899_A1Up0.9973368030
GSE19899_A2Up7.0845120375
PubMed_21979375_A1Up7.0586846265
PubMed_21979375_A2Up7.2937460696
GSE35957Down-0.5067553887
GSE36640Up1.0453842004
GSE54402Up5.2850877085
GSE9593Down-0.0684653562
GSE43922Up2.7180181676
GSE24585Down-0.1068783006
GSE37065Up0.8036963786
GSE28863_A1Down-0.2235690322
GSE28863_A2Down-2.7703248586
GSE28863_A3Down-0.6703495009
GSE28863_A4Down-0.1706749882
GSE48662Up0.0341006659

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MarimastatDB00786 APRD00559
CP-271485DB02118 EXPT00996
PF-00356231DB03367 EXPT02553
BatimastatDB03880 EXPT00627
2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic AcidDB04405 EXPT01160
AE-941DB05387 -
(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDEDB07026 -
N-(biphenyl-4-ylsulfonyl)-D-leucineDB07446 -
N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDEDB07556 -
N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valineDB07683 -
N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamideDB07920 -
2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamideDB07921 -
N-oxo-2-(phenylsulfonylamino)ethanamideDB07922 -
N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACIDDB08271 -
N-[(4-methoxyphenyl)sulfonyl]-D-alanineDB08599 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-145-5pMIMAT0000437MIRT021521Reporter assay;MicroarrayFunctional MTI21351259
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.