HCSGD entry for ASTL


1. General information

Official gene symbolASTL
Entrez ID431705
Gene full nameastacin-like metallo-endopeptidase (M12 family)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004222Metalloendopeptidase activityIDAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005886Plasma membraneISScellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0007155Cell adhesionISSbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009566FertilizationISSbiological_process
GO:0010954Positive regulation of protein processingISSbiological_process
GO:0030133Transport vesicleIEAcellular_component
GO:0060468Prevention of polyspermyISSbiological_process
GO:0060473Cortical granuleISScellular_component
GO:0070001Aspartic-type peptidase activityISSmolecular_function
GO:0070002Glutamic-type peptidase activityISSmolecular_function
GO:2000360Negative regulation of binding of sperm to zona pellucidaISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48907172220.95357068120.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.1035142129
GSE24585Down-0.0233735360
GSE37065Down-0.0634798462
GSE28863_A1Up0.0427941113
GSE28863_A2Up0.2219359898
GSE28863_A3Up0.3423684527
GSE28863_A4Down-0.0505176704
GSE48662Up0.0580779647

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1226-3pMIMAT0005577MIRT036503CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.