HCSGD entry for MMP3
1. General information
| Official gene symbol | MMP3 |
|---|---|
| Entrez ID | 4314 |
| Gene full name | matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| Other gene symbols | CHDS6 MMP-3 SL-1 STMY STMY1 STR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004222 | Metalloendopeptidase activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0071230 | Cellular response to amino acid stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000086585 | 0.0705234490 | 0.0115777778 | 0.5014778498 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 6.4384109394 |
| GSE13712_SHEAR | Up | 0.0024285674 |
| GSE13712_STATIC | Down | -0.1252002318 |
| GSE19018 | Up | 0.9090938161 |
| GSE19899_A1 | Up | 5.6077199069 |
| GSE19899_A2 | Up | 3.9538736668 |
| PubMed_21979375_A1 | Up | 8.9390015338 |
| PubMed_21979375_A2 | Up | 8.6837712201 |
| GSE35957 | Down | -2.1008128889 |
| GSE36640 | Up | 4.0537764944 |
| GSE54402 | Up | 2.1732427860 |
| GSE9593 | Down | -0.1398207250 |
| GSE43922 | Up | 6.6326474573 |
| GSE24585 | Up | 0.1871574464 |
| GSE37065 | Up | 1.4828500990 |
| GSE28863_A1 | Down | -0.9399425375 |
| GSE28863_A2 | Down | -1.4728025902 |
| GSE28863_A3 | Down | -0.2771409498 |
| GSE28863_A4 | Down | -0.3731849957 |
| GSE48662 | Up | 0.0862649382 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Marimastat | DB00786 | APRD00559 |
| N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide | DB01877 | EXPT02941 |
| 3-Methylpyridine | DB01996 | EXPT00181 |
| A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor | DB02090 | EXPT02835 |
| N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide | DB02350 | EXPT02193 |
| (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine | DB02367 | EXPT00010 |
| 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid | DB02449 | EXPT01260 |
| Hydroxyaminovaline | DB02697 | EXPT01693 |
| 1-Methyloxy-4-Sulfone-Benzene | DB03033 | EXPT02236 |
| 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione | DB03368 | EXPT01778 |
| 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide | DB04140 | EXPT00633 |
| N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide | DB04232 | EXPT02946 |
| R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid | DB04416 | EXPT02128 |
| 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE | DB07390 | - |
| [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID | DB07986 | - |
| [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER | DB07987 | - |
| 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE | DB07988 | - |
| N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide | DB08029 | - |
| 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide | DB08030 | - |
| N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | DB08271 | - |
| N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID | DB08507 | - |
| 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER | DB08643 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT021683 | qRT-PCR | Functional MTI (Weak) | 21770894 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 11 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27883166 | 4 pg/ml) and MMP-3 (26 vs 23 |
| 26883561 | These antifibrotic effects are associated with increased fibrin metabolism, enhanced matrix metalloproteinase-3 expression, and reduced senescence in type 2 pneumocytes |
| 26284488 | The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1 |
| 24665044 | SASP markers, MMP-1/MMP-3 were significantly higher in the WSL but not IL-6/IL-8 |
| 24475901 | In addition, mRNA levels of matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1, and concentration of beta-galactose were all measured to confirm cell senescence |
| 23030720 | The mRNA levels of MMP-1, MMP-3 and type I (alpha1) collagen were determined by quantitative real-time PCR |
| 23030720 | Moreover, 10-HDA suppressed the UVA-induced expression of MMP-1 and MMP-3 at both the transcriptional and protein levels |
| 23030720 | CONCLUSION: The data obtained in this study provide evidence that 10-HDA could prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions |
| 22500976 | AIR promoted MMP-3 and inhibited MMP-1 appearance to some extent, but did not affect expression of other major MMPs |
| 22454193 | RESULTS: Chondrocytes stimulated by IL-1beta showed increased MMP-1, MMP-3, and MMP-13 levels, whereas the expression of COL2A1 and ACAN decreased |
| 19058142 | After 7 days, DNA and sulfated glycosaminoglycan contents were analyzed along with real time, quantitative reverse transcription-polymerase chain reaction analysis for collagen types I and II, aggrecan, and matrix metalloproteinase-3 gene expression |
| 15657080 | Furthermore, we identify MMP-3 as the major factor responsible for the effects of senescent fibroblasts on branching morphogenesis |
| 9472004 | 8-fold up-regulation of two matrix-degrading enzymes, interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3), over a period of >120 days, while TIMP-1, the major inhibitor of MMP-1 and MMP-3, was only slightly induced |
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