HCSGD entry for ACHE

1. General information

Official gene symbolACHE
Entrez ID43
Gene full nameacetylcholinesterase
Other gene symbolsACEE ARACHE N-ACHE YT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001507Acetylcholine catabolic process in synaptic cleftNASbiological_process
GO:0001540Beta-amyloid bindingTASmolecular_function
GO:0001919Regulation of receptor recyclingIEAbiological_process
GO:0002076Osteoblast developmentIEPbiological_process
GO:0003990Acetylcholinesterase activityIDA IEA IMPmolecular_function
GO:0004104Cholinesterase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIDAmolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005605Basal laminaIEA NAScellular_component
GO:0005615Extracellular spaceIBA IEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005788Endoplasmic reticulum lumenIBAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0006260DNA replicationTASbiological_process
GO:0006581Acetylcholine catabolic processIDA IEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006656Phosphatidylcholine biosynthetic processTASbiological_process
GO:0007155Cell adhesionIDA TASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007271Synaptic transmission, cholinergicIBAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007416Synapse assemblyIBA TASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0009986Cell surfaceIBA IEAcellular_component
GO:0016020MembraneIDAcellular_component
GO:0016787Hydrolase activityIDAmolecular_function
GO:0017171Serine hydrolase activityIDAmolecular_function
GO:0019695Choline metabolic processIBAbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030424AxonIBAcellular_component
GO:0030425DendriteIBAcellular_component
GO:0031225Anchored component of membraneIEAcellular_component
GO:0031594Neuromuscular junctionIBA IEAcellular_component
GO:0031623Receptor internalizationIEAbiological_process
GO:0032223Negative regulation of synaptic transmission, cholinergicICbiological_process
GO:0042136Neurotransmitter biosynthetic processTASbiological_process
GO:0042166Acetylcholine bindingIDA NASmolecular_function
GO:0042734Presynaptic membraneIBAcellular_component
GO:0042803Protein homodimerization activityIPI NASmolecular_function
GO:0042982Amyloid precursor protein metabolic processTASbiological_process
GO:0043236Laminin bindingIDA IEAmolecular_function
GO:0043621Protein self-associationIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045202SynapseIDAcellular_component
GO:0045211Postsynaptic membraneIBAcellular_component
GO:0045212Neurotransmitter receptor biosynthetic processIEAbiological_process
GO:0046474Glycerophospholipid biosynthetic processTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048814Regulation of dendrite morphogenesisIBAbiological_process
GO:0050714Positive regulation of protein secretionTASbiological_process
GO:0050770Regulation of axonogenesisIBAbiological_process
GO:0051262Protein tetramerizationIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52445937460.85584272630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0520050637
GSE13712_SHEARDown-0.0628781649
GSE13712_STATICDown-0.2455641436
GSE19018Up0.0841017306
GSE19899_A1Down-0.0715228178
GSE19899_A2Up0.1981544085
PubMed_21979375_A1Down-0.0443470230
PubMed_21979375_A2Down-0.1506464672
GSE35957Up0.1238589866
GSE36640Up0.0963725556
GSE54402Down-0.0740044009
GSE9593Up0.1115158886
GSE43922Up0.1007734467
GSE24585Up0.2194423465
GSE37065Down-0.0332995069
GSE28863_A1Down-0.1533619807
GSE28863_A2Down-0.0703084497
GSE28863_A3Up0.3535787887
GSE28863_A4Up0.1094023341
GSE48662Up0.3945106805

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16187225Here, we present evidence to the fact that these two distinct phenomena both associate with specific changes in acetylcholinesterase (AChE) gene expression within cholinergic neurons
10698358Acetylcholinesterase activity in chronic renal failure
10698358Twenty healthy subjects and 39 Chronic Renal Failure patients (CRF-patients) maintained on chronic hemodialysis were used in this investigation to study the changes in acetylcholinesterase (AChE) activity of red blood cells (RBCs)
9698047Acetylcholinesterase: an enzymatic marker of human red blood cell aging
9698047The purpose of this investigation was to determine whether acetylcholinesterase (AChE) can be used as a marker of cell aging in human red blood cells (RBCs)
1764909The activities of six enzymes: glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), hexokinase (Hx), glutamate oxaloacetate transminase (GOT), lactate dehydrogenase (LDH) and acetylcholinesterase (AChE), were measured in the red cells of different ages which were obtained either by centrifugation or experimental anaemia
6617629Changes in kinetic properties of acetylcholinesterase
6617629Comparison of kinetic properties of acetylcholinesterase in membrane preparations from various density (age) fractions of bovine erythrocytes revealed in increase in Km value, ascribed to decrease in membrane surface potential, with increasing cell age
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