HCSGD entry for MAP3K9
1. General information
| Official gene symbol | MAP3K9 |
|---|---|
| Entrez ID | 4293 |
| Gene full name | mitogen-activated protein kinase kinase kinase 9 |
| Other gene symbols | MEKK9 MLK1 PRKE1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | ISS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0004706 | JUN kinase kinase kinase activity | ISS | molecular_function |
| GO:0004708 | MAP kinase kinase activity | NAS | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007256 | Activation of JNKK activity | ISS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | ISS | biological_process |
| GO:0042803 | Protein homodimerization activity | ISS | molecular_function |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0248706356 | 0.9825500171 | 0.3720187181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0819396090 |
| GSE13712_SHEAR | Up | 0.0214444330 |
| GSE13712_STATIC | Up | 0.0234120485 |
| GSE19018 | Up | 0.0428097792 |
| GSE19899_A1 | Up | 0.2779598125 |
| GSE19899_A2 | Up | 0.9698361250 |
| PubMed_21979375_A1 | Up | 1.8112909200 |
| PubMed_21979375_A2 | Up | 1.2263356332 |
| GSE35957 | Down | -0.0295113002 |
| GSE36640 | Down | -0.1305795710 |
| GSE54402 | Up | 0.7043439208 |
| GSE9593 | Up | 0.1432991942 |
| GSE43922 | Up | 0.3096248359 |
| GSE24585 | Down | -0.0518980292 |
| GSE37065 | Up | 0.0714604146 |
| GSE28863_A1 | Up | 0.0679670744 |
| GSE28863_A2 | Down | -0.0950304558 |
| GSE28863_A3 | Up | 0.2830376034 |
| GSE28863_A4 | Up | 0.0854299312 |
| GSE48662 | Up | 0.0632941131 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one | DB08703 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT005606 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 21266077 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042797 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051042 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
