HCSGD entry for MITF

1. General information

Official gene symbolMITF
Entrez ID4286
Gene full namemicrophthalmia-associated transcription factor
Other gene symbolsCMM8 MI WS2 WS2A bHLHe32
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA NAScellular_component
GO:0006355Regulation of transcription, DNA-templatedIEA NASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006461Protein complex assemblyIDAbiological_process
GO:0030316Osteoclast differentiationIEAbiological_process
GO:0030318Melanocyte differentiationIEA NASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0043010Camera-type eye developmentIEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0044336Canonical Wnt signaling pathway involved in negative regulation of apoptotic processIEAbiological_process
GO:0045165Cell fate commitmentIEAbiological_process
GO:0045670Regulation of osteoclast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA NASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0046849Bone remodelingIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04485081110.51934382810.47072645421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2411201175
GSE13712_SHEARDown-0.4199743769
GSE13712_STATICUp0.0024382271
GSE19018Up0.1250999647
GSE19899_A1Down-0.4744438122
GSE19899_A2Up0.2350603683
PubMed_21979375_A1Up1.3762280635
PubMed_21979375_A2Up0.9433672040
GSE35957Up0.1210411846
GSE36640Up1.1132440837
GSE54402Down-1.0881276472
GSE9593Up0.4777041933
GSE43922Down-0.1516179092
GSE24585Up0.0095798042
GSE37065Up0.0018890354
GSE28863_A1Up0.0262111939
GSE28863_A2Up0.6172536002
GSE28863_A3Up0.2676157821
GSE28863_A4Up0.0561993323
GSE48662Up0.1129450186

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-182-5pMIMAT0000259MIRT001990Flow//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22848417
hsa-miR-137MIMAT0000429MIRT005883Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21051724
hsa-miR-155-5pMIMAT0000646MIRT006969Luciferase reporter assayFunctional MTI22771905
hsa-miR-98-5pMIMAT0000096MIRT027612MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-96-5pMIMAT00000952hsa-miR-9617597072
hsa-miR-96-5pMIMAT00000953hsa-miR-9617597072
hsa-miR-96-5pMIMAT00000951hsa-miR-9617597072
hsa-miR-96-5pMIMAT00000954hsa-miR-9617597072
hsa-miR-182-5pMIMAT00002594hsa-miR-18217597072
hsa-miR-182-5pMIMAT00002591hsa-miR-18217597072
hsa-miR-182-5pMIMAT00002593hsa-miR-18217597072
hsa-miR-182-5pMIMAT00002592hsa-miR-18217597072
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26824319The activity of the M isoform of microphthalmia-associated transcription factor (MITF-M) has been attributed to regulation of differentiation, proliferation, survival and senescence of melanoma cells
26824319MITF expression was shown to be antagonized by the activation of transcription factor NF-kappaB
26003288MITF, a melanoma oncogene member of the microphthalmia family of transcription factors (MiT), was recently found to contain novel GSK3 phosphorylation sites and to be stabilized by Wnt
26003288Recent studies suggest that MITF can also upregulate many lysosomal genes
26003288Here we review the role of MiT members, including MITF, in lysosomal biogenesis, and how cancers overexpressing MITF, TFEB or TFE3 could rewire the lysosomal pathway, inhibit cellular senescence, and activate Wnt signaling by increasing sequestration of negative regulators of Wnt signaling in multivesicular bodies (MVBs)
26003288Microarray studies suggest that MITF expression inhibits macroautophagy
26003288In melanoma the MITF-driven increase in MVBs generates a positive feedback loop between MITF, Wnt, and MVBs
21258399The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-specific 'oncogene' that has a critical role in the pathogenesis of melanoma
21258399MITF promotes melanoma cell proliferation, whereas sustained supression of MITF expression leads to senescence
21258399By combining chromatin immunoprecipitation coupled to high throughput sequencing (ChIP-seq) and RNA sequencing analyses, we show that MITF directly regulates a set of genes required for DNA replication, repair and mitosis
21258399Our results reveal how loss of MITF regulates mitotic fidelity, and through defective replication and repair induces DNA damage, ultimately ending in cellular senescence
21258399These findings reveal a lineage-specific control of DNA replication and mitosis by MITF, providing new avenues for therapeutic intervention in melanoma
15892717Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes
15892717We have previously demonstrated that the melanocyte transcriptional regulator microphthalmia-associated protein (MITF) is down-regulated in senescent melanocytes
15892717Electrophoresis gel-shift analysis using an oligonucleotide containing MITF and ERE elements identified MITF and ER-alpha complexes in proliferating melanocytes, whereas only ER-alpha complexes were detected in senescent cells
15892717Importantly, a promoter-reporter analysis demonstrated that the coactivator p300/CBP switched MITF from a repressor to an activator of DCT transcription
11846374Senescence is characterized by downregulation of Id4, inhibitor of DNA binding 4, and Mitf, microphthalmia-associated transcription factor, in comparison with young replicating and quiescent states
Entries Per Page
Displaying Page of