HCSGD entry for MGST1

1. General information

Official gene symbolMGST1
Entrez ID4257
Gene full namemicrosomal glutathione S-transferase 1
Other gene symbolsGST12 MGST MGST-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004364Glutathione transferase activityIDA IEAmolecular_function
GO:0004602Glutathione peroxidase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005778Peroxisomal membraneIEA ISScellular_component
GO:0005783Endoplasmic reticulumIEA ISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006749Glutathione metabolic processIEAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0016021Integral component of membraneIEA ISScellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043295Glutathione bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070207Protein homotrimerizationIEA ISSbiological_process
GO:0071449Cellular response to lipid hydroperoxideIDAbiological_process
GO:1901687Glutathione derivative biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42889101100.21421120020.99999024730.8935424723

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2476350690
GSE13712_SHEARUp0.5708272177
GSE13712_STATICUp0.4188357131
GSE19018Down-0.1076922188
GSE19899_A1Down-0.2940827609
GSE19899_A2Down-0.4573587192
PubMed_21979375_A1Down-0.5440145311
PubMed_21979375_A2Down-0.1532985045
GSE35957Up0.1025956712
GSE36640Up0.4200748834
GSE54402Down-0.0870030178
GSE9593Up0.0382737082
GSE43922Down-0.1514692904
GSE24585Down-0.4244951827
GSE37065Up0.2956322800
GSE28863_A1Up0.2805011098
GSE28863_A2Up0.1241488118
GSE28863_A3Down-0.3668996995
GSE28863_A4Down-0.0057270733
GSE48662Down-0.2877860328

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GlutathioneDB00143 NUTR00029 | EXPT01650

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-96-5pMIMAT0000095MIRT027876SequencingFunctional MTI (Weak)20371350
hsa-miR-652-3pMIMAT0003322MIRT039484CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.