HCSGD entry for MEOX1
1. General information
| Official gene symbol | MEOX1 |
|---|---|
| Entrez ID | 4222 |
| Gene full name | mesenchyme homeobox 1 |
| Other gene symbols | KFS2 MOX1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001757 | Somite specification | IEA | biological_process |
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0071837 | HMG box domain binding | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3095087725 | 0.9117223662 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1771116387 |
| GSE13712_SHEAR | Up | 0.0160052670 |
| GSE13712_STATIC | Down | -0.0843635227 |
| GSE19018 | Up | 0.1103397342 |
| GSE19899_A1 | Up | 0.0232709813 |
| GSE19899_A2 | Up | 0.0652980492 |
| PubMed_21979375_A1 | Down | -0.0078382519 |
| PubMed_21979375_A2 | Up | 0.1698804734 |
| GSE35957 | Up | 0.5091972033 |
| GSE36640 | Up | 0.0370351251 |
| GSE54402 | Down | -0.0966567941 |
| GSE9593 | Up | 0.1141987967 |
| GSE43922 | Up | 0.0494906435 |
| GSE24585 | Up | 0.0744331640 |
| GSE37065 | Down | -0.0516705497 |
| GSE28863_A1 | Down | -0.0723166909 |
| GSE28863_A2 | Down | -0.2151261972 |
| GSE28863_A3 | Up | 0.3404687311 |
| GSE28863_A4 | Up | 0.2042153465 |
| GSE48662 | Down | -0.0201605733 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22206000 | Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells |
| 22206000 | MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes in vivo |
| 22206000 | We compared the ability of MEOX1 and MEOX2 to activate p21(CIP1/WAF1) and p16(INK4a) expression and induce endothelial cell cycle arrest |
| 22206000 | Our results demonstrate for the first time that MEOX1 regulates the MEOX2 target genes p21(CIP1/WAF1) and p16(INK4a) |
| 22206000 | Furthermore, we show that the mechanism of transcriptional activation of these cyclin dependent kinase inhibitor genes by MEOX1 and MEOX2 is distinct |
| 22206000 | MEOX1 and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1) in a DNA binding independent manner |
Entries Per Page
Displaying Page of
