HCSGD entry for MAP3K4
1. General information
| Official gene symbol | MAP3K4 |
|---|---|
| Entrez ID | 4216 |
| Gene full name | mitogen-activated protein kinase kinase kinase 4 |
| Other gene symbols | MAPKKK4 MEKK4 MTK1 PRO0412 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | IDA | biological_process |
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0001890 | Placenta development | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004709 | MAP kinase kinase kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0010225 | Response to UV-C | IMP | biological_process |
| GO:0010468 | Regulation of gene expression | IEA | biological_process |
| GO:0019100 | Male germ-line sex determination | IEA | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | ISS | biological_process |
| GO:0043507 | Positive regulation of JUN kinase activity | IDA IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0060718 | Chorionic trophoblast cell differentiation | IEA | biological_process |
| GO:1900745 | Positive regulation of p38MAPK cascade | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1142663767 | 0.1020833593 | 0.6952531409 | 0.6121977899 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3763645731 |
| GSE13712_SHEAR | Down | -0.9283569980 |
| GSE13712_STATIC | Down | -0.5211731449 |
| GSE19018 | Down | -0.2191634968 |
| GSE19899_A1 | Up | 0.2441421353 |
| GSE19899_A2 | Down | -0.3266447421 |
| PubMed_21979375_A1 | Up | 0.3431976438 |
| PubMed_21979375_A2 | Up | 0.4989481012 |
| GSE35957 | Down | -0.3017611363 |
| GSE36640 | Down | -0.6713379155 |
| GSE54402 | Up | 0.4278755832 |
| GSE9593 | Down | -0.8818365134 |
| GSE43922 | Up | 0.1675459081 |
| GSE24585 | Down | -0.2793226885 |
| GSE37065 | Up | 0.1718778300 |
| GSE28863_A1 | Up | 1.0775719727 |
| GSE28863_A2 | Up | 1.0092601304 |
| GSE28863_A3 | Down | -0.2012905096 |
| GSE28863_A4 | Down | -0.3651631437 |
| GSE48662 | Up | 0.0995781341 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022893 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT048040 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048846 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049769 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18801192 | RESULTS: We confirm the validity of this screen and show that ING1 interacts specifically with three of the three proteins tested; p38MAPK, MEKK4 and RAD50 |
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