HCSGD entry for MEF2C

1. General information

Official gene symbolMEF2C
Entrez ID4208
Gene full namemyocyte enhancer factor 2C
Other gene symbolsC5DELq14.3 DEL5q14.3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000002Mitochondrial genome maintenanceIEAbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000165MAPK cascadeIDA IEA IMPbiological_process
GO:0000790Nuclear chromatinIEAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDA IEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityISSmolecular_function
GO:0000983RNA polymerase II core promoter sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIEAmolecular_function
GO:0001046Core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA IEAmolecular_function
GO:0001568Blood vessel developmentIEA ISSbiological_process
GO:0001649Osteoblast differentiationIEA ISSbiological_process
GO:0001782B cell homeostasisIEA ISSbiological_process
GO:0001947Heart loopingIEA ISSbiological_process
GO:0001958Endochondral ossificationIEA ISSbiological_process
GO:0001974Blood vessel remodelingIEA ISSbiological_process
GO:0002062Chondrocyte differentiationIEA ISSbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002467Germinal center formationIEA ISSbiological_process
GO:0002634Regulation of germinal center formationIEA ISSbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003138Primary heart field specificationIEA ISSbiological_process
GO:0003139Secondary heart field specificationIEA ISSbiological_process
GO:0003151Outflow tract morphogenesisIEA ISSbiological_process
GO:0003185Sinoatrial valve morphogenesisIEA ISSbiological_process
GO:0003211Cardiac ventricle formationIEA ISSbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003680AT DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006959Humoral immune responseIEA ISSbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0007507Heart developmentIEP ISS NASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0007519Skeletal muscle tissue developmentIEA ISSbiological_process
GO:0007521Muscle cell fate determinationIEA ISSbiological_process
GO:0007611Learning or memoryIEA ISSbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010629Negative regulation of gene expressionIEA ISSbiological_process
GO:0010694Positive regulation of alkaline phosphatase activityIEA ISSbiological_process
GO:0014033Neural crest cell differentiationIEA ISSbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0014902Myotube differentiationIEPbiological_process
GO:0016607Nuclear speckIDAcellular_component
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0021542Dentate gyrus developmentIEAbiological_process
GO:0030017SarcomereIEAcellular_component
GO:0030182Neuron differentiationIEP ISSbiological_process
GO:0030220Platelet formationIEA ISSbiological_process
GO:0030224Monocyte differentiationIEAbiological_process
GO:0030279Negative regulation of ossificationIDAbiological_process
GO:0030318Melanocyte differentiationIEA ISSbiological_process
GO:0030501Positive regulation of bone mineralizationIEA ISSbiological_process
GO:0030890Positive regulation of B cell proliferationIEA ISSbiological_process
GO:0033197Response to vitamin EIEAbiological_process
GO:0033613Activating transcription factor bindingIEA IPImolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035198MiRNA bindingIDAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035690Cellular response to drugIEA ISSbiological_process
GO:0035984Cellular response to trichostatin AIEA ISSbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042100B cell proliferationIEA ISSbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0042826Histone deacetylase bindingIEAmolecular_function
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043234Protein complexIDAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIEA ISSbiological_process
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045652Regulation of megakaryocyte differentiationIEA ISSbiological_process
GO:0045663Positive regulation of myoblast differentiationIMPbiological_process
GO:0045666Positive regulation of neuron differentiationIEA ISSbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEA ISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048311Mitochondrion distributionIEAbiological_process
GO:0048643Positive regulation of skeletal muscle tissue developmentIMPbiological_process
GO:0048666Neuron developmentIEA ISSbiological_process
GO:0048703Embryonic viscerocranium morphogenesisIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050853B cell receptor signaling pathwayIEA ISSbiological_process
GO:0051145Smooth muscle cell differentiationIEA ISSbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0055005Ventricular cardiac myofibril assemblyIEAbiological_process
GO:0055012Ventricular cardiac muscle cell differentiationIEA ISSbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060025Regulation of synaptic activityIEA ISSbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEA ISSbiological_process
GO:0060297Regulation of sarcomere organizationIEAbiological_process
GO:0060536Cartilage morphogenesisIEAbiological_process
GO:0061333Renal tubule morphogenesisISSbiological_process
GO:0061337Cardiac conductionIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEA ISSbiological_process
GO:0071277Cellular response to calcium ionIEA ISSbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071374Cellular response to parathyroid hormone stimulusIDAbiological_process
GO:0071498Cellular response to fluid shear stressIEA ISSbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIDAbiological_process
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0071864Positive regulation of cell proliferation in bone marrowIEAbiological_process
GO:0072102Glomerulus morphogenesisIEA ISSbiological_process
GO:0072160Nephron tubule epithelial cell differentiationIEA ISSbiological_process
GO:0090073Positive regulation of protein homodimerization activityIEA ISSbiological_process
GO:2000111Positive regulation of macrophage apoptotic processIEA ISSbiological_process
GO:2000727Positive regulation of cardiac muscle cell differentiationIDA IEAbiological_process
GO:2000987Positive regulation of behavioral fear responseIEA ISSbiological_process
GO:2001013Epithelial cell proliferation involved in renal tubule morphogenesisIEA ISSbiological_process
GO:2001016Positive regulation of skeletal muscle cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56943392350.02908457890.99999024730.3232834459

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4785827633
GSE13712_SHEARDown-0.4420392224
GSE13712_STATICDown-0.0737108075
GSE19018Down-0.5517134216
GSE19899_A1Up0.0015165050
GSE19899_A2Up0.1933125012
PubMed_21979375_A1Down-1.0818929823
PubMed_21979375_A2Up0.0611095468
GSE35957Down-0.5818843343
GSE36640Down-0.1494881092
GSE54402Up0.5120144724
GSE9593Down-0.4053387699
GSE43922Up0.4523794211
GSE24585Down-0.3772304056
GSE37065Up0.3170948084
GSE28863_A1Down-0.0216937645
GSE28863_A2Down-0.6161084077
GSE28863_A3Down-0.5171761552
GSE28863_A4Down-0.1463699639
GSE48662Down-0.8115065102

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-223-3pMIMAT0000280MIRT000128Luciferase reporter assayFunctional MTI18278031
hsa-miR-223-3pMIMAT0000280MIRT000128Immunofluorescence//qRT-PCR//Western blotNon-Functional MTI23094093
hsa-miR-21-5pMIMAT0000076MIRT005737Immunofluorescence//In situ hybridization//Luciferase reporter assayFunctional MTI21170291
hsa-miR-26b-5pMIMAT0000083MIRT029032MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92a-3pMIMAT0000092MIRT049691CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051852CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052262CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.