HCSGD entry for MECP2

1. General information

Official gene symbolMECP2
Entrez ID4204
Gene full namemethyl CpG binding protein 2 (Rett syndrome)
Other gene symbolsAUTSX3 MRX16 MRX79 MRXS13 MRXSL PPMX RS RTS RTT
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0000792HeterochromatinIDAcellular_component
GO:0001662Behavioral fear responseIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001964Startle responseIEAbiological_process
GO:0001976Neurological system process involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0002087Regulation of respiratory gaseous exchange by neurological system processIEAbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0003729MRNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006020Inositol metabolic processIEAbiological_process
GO:0006122Mitochondrial electron transport, ubiquinol to cytochrome cIEAbiological_process
GO:0006342Chromatin silencingIEAbiological_process
GO:0006349Regulation of gene expression by genetic imprintingIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006541Glutamine metabolic processIEAbiological_process
GO:0007416Synapse assemblyIEAbiological_process
GO:0007585Respiratory gaseous exchangeIEAbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008211Glucocorticoid metabolic processIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008327Methyl-CpG bindingIEAmolecular_function
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008542Visual learningIEAbiological_process
GO:0009405PathogenesisIEAbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0010385Double-stranded methylated DNA bindingIMPmolecular_function
GO:0016358Dendrite developmentIEAbiological_process
GO:0016571Histone methylationIEAbiological_process
GO:0016573Histone acetylationIEAbiological_process
GO:0019230ProprioceptionIEAbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0021549Cerebellum developmentIEAbiological_process
GO:0021591Ventricular system developmentIEAbiological_process
GO:0031061Negative regulation of histone methylationIEAbiological_process
GO:0032048Cardiolipin metabolic processIEAbiological_process
GO:0035067Negative regulation of histone acetylationIEAbiological_process
GO:0035176Social behaviorIEAbiological_process
GO:0035197SiRNA bindingIEAmolecular_function
GO:0042551Neuron maturationIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046470Phosphatidylcholine metabolic processIEAbiological_process
GO:0047485Protein N-terminus bindingIPImolecular_function
GO:0050432Catecholamine secretionIEAbiological_process
GO:0051965Positive regulation of synapse assemblyIEAbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25830885220.84876164660.95223437891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2240523139
GSE13712_SHEARDown-0.0419126022
GSE13712_STATICUp0.1756022276
GSE19018Up0.0653561352
GSE19899_A1Down-0.1274080123
GSE19899_A2Up0.1697027350
PubMed_21979375_A1Down-0.0367795692
PubMed_21979375_A2Up0.3409967861
GSE35957Up0.2380112776
GSE36640Up0.1117531883
GSE54402Up0.1970411815
GSE9593Up0.2409816738
GSE43922Down-0.0552554109
GSE24585Up0.1955833400
GSE37065Up0.0392210967
GSE28863_A1Up0.6375602868
GSE28863_A2Up0.3001512548
GSE28863_A3Down-0.2013414923
GSE28863_A4Up0.0165044164
GSE48662Down-0.1512360576

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-802MIMAT0004185MIRT000441Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19897480
hsa-miR-802MIMAT0004185MIRT000441Luciferase reporter assay//qRT-PCR//MicroarrayFunctional MTI20388499
hsa-miR-155-5pMIMAT0000646MIRT000442Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19897480
hsa-miR-155-5pMIMAT0000646MIRT000442Luciferase reporter assay//qRT-PCR//MicroarrayFunctional MTI20388499
hsa-miR-199a-3pMIMAT0000232MIRT000779Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-195-5pMIMAT0000461MIRT000795Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-19a-3pMIMAT0000073MIRT001795Luciferase reporter assay//Reporter assay;Microarray;OtherFunctional MTI14697198
hsa-miR-19a-3pMIMAT0000073MIRT001795Reporter assay;OtherNon-Functional MTI18460397
hsa-miR-122-5pMIMAT0000421MIRT003089Luciferase reporter assay//qRT-PCRFunctional MTI19296470
hsa-miR-212-3pMIMAT0000269MIRT003897Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;Microarray;OtherFunctional MTI20020497
hsa-miR-199a-5pMIMAT0000231MIRT004395Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-124-3pMIMAT0000422MIRT007282Luciferase reporter assayFunctional MTI23318130
hsa-miR-148b-3pMIMAT0000759MIRT019389MicroarrayFunctional MTI (Weak)17612493
hsa-miR-425-3pMIMAT0001343MIRT042431CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043437CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049717CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-155-5pMIMAT00006461hsa-miR-155{Western blot}{overexpression by miRNA mimics tranfection}19897480
hsa-miR-155-5pMIMAT00006462hsa-miR-155{Western blot}{overexpression by miRNA mimics tranfection}19897480
hsa-miR-802MIMAT00041851hsa-miR-802{Western blot}{overexpression by miRNA mimics tranfection}19897480
hsa-miR-802MIMAT00041852hsa-miR-802{Western blot}{overexpression by miRNA mimics tranfection}19897480
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18723031The levels of DNMT3b and methyl-CpG binding protein 2 (MeCP2) increased in both mid-aged and replicative senescent cells, while DNMT3a and MBD2 were upregulated in the mid-aged cells
18723031Additionally, the expression for DNMTs, MBD2 and MeCP2 was increased rapidly upon H(2)O(2) treatment
18513492Mutation or methylation of lysine 9, a mark well known for repression, abrogates histone methylation by MeCP2 but not by the p33ING2 complex
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