HCSGD entry for ME2
1. General information
| Official gene symbol | ME2 |
|---|---|
| Entrez ID | 4200 |
| Gene full name | malic enzyme 2, NAD(+)-dependent, mitochondrial |
| Other gene symbols | ODS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004471 | Malate dehydrogenase (decarboxylating) (NAD+) activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0006108 | Malate metabolic process | IEA | biological_process |
| GO:0008948 | Oxaloacetate decarboxylase activity | IEA | molecular_function |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9440879146 | 0.0287643365 | 0.9999902473 | 0.3221988936 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0443962255 |
| GSE13712_SHEAR | Down | -0.0978536672 |
| GSE13712_STATIC | Up | 0.1973414276 |
| GSE19018 | Up | 0.0498284519 |
| GSE19899_A1 | Down | -0.2184302894 |
| GSE19899_A2 | Down | -0.1940429862 |
| PubMed_21979375_A1 | Down | -0.2036535585 |
| PubMed_21979375_A2 | Down | -0.1595583684 |
| GSE35957 | Down | -0.4410490184 |
| GSE36640 | Down | -0.5690633412 |
| GSE54402 | Down | -0.0474591891 |
| GSE9593 | Down | -0.3255238168 |
| GSE43922 | Down | -0.0500244403 |
| GSE24585 | Down | -0.6229873764 |
| GSE37065 | Up | 0.1837516302 |
| GSE28863_A1 | Up | 0.0326434817 |
| GSE28863_A2 | Up | 0.3237192704 |
| GSE28863_A3 | Down | -0.6460625267 |
| GSE28863_A4 | Down | -0.1050570385 |
| GSE48662 | Down | -0.7875858393 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Fumarate | DB01677 | EXPT01460 | EXPT01511 |
| Malate Ion | DB03499 | EXPT02188 |
| Alpha-Ketomalonic Acid | DB03589 | EXPT02110 |
| Tartronate | DB03680 | EXPT03129 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049487 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26008970 | A small-molecule inhibitor suppresses the tumor-associated mitochondrial NAD(P)+-dependent malic enzyme (ME2) and induces cellular senescence |
| 26008970 | Here, we found a natural compound, embonic acid (EA), that can specifically inhibit the enzymatic activity of mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME, ME2) either in vitro or in vivo |
| 26008970 | Therefore, the EA-evoked senescence of H1299 cells may occur directly through the inhibition of ME2 or a p53-independent pathway |
| 23334421 | We show that p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells |
| 23334421 | Both malic enzymes are important for NADPH production, lipogenesis and glutamine metabolism, but ME2 has a more profound effect |
| 23334421 | Downregulation of ME1 and ME2 reciprocally activates p53 through distinct MDM2- and AMP-activated protein kinase-mediated mechanisms in a feed-forward manner, bolstering this pathway and enhancing p53 activation |
| 23334421 | Downregulation of ME1 and ME2 also modulates the outcome of p53 activation, leading to strong induction of senescence, but not apoptosis, whereas enforced expression of either malic enzyme suppresses senescence |
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