HCSGD entry for ME1
1. General information
| Official gene symbol | ME1 |
|---|---|
| Entrez ID | 4199 |
| Gene full name | malic enzyme 1, NADP(+)-dependent, cytosolic |
| Other gene symbols | HUMNDME MES |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004470 | Malic enzyme activity | IDA | molecular_function |
| GO:0004471 | Malate dehydrogenase (decarboxylating) (NAD+) activity | IEA | molecular_function |
| GO:0004473 | Malate dehydrogenase (decarboxylating) (NADP+) activity | IDA ISS | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | ISS TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | NAS | biological_process |
| GO:0006108 | Malate metabolic process | IDA IEA | biological_process |
| GO:0006741 | NADP biosynthetic process | TAS | biological_process |
| GO:0008948 | Oxaloacetate decarboxylase activity | IEA | molecular_function |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0009725 | Response to hormone | ISS | biological_process |
| GO:0009743 | Response to carbohydrate | TAS | biological_process |
| GO:0030145 | Manganese ion binding | IDA | molecular_function |
| GO:0043531 | ADP binding | TAS | molecular_function |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050661 | NADP binding | TAS | molecular_function |
| GO:0051262 | Protein tetramerization | IEA | biological_process |
| GO:0051287 | NAD binding | IEA TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2364497701 | 0.1082263212 | 0.9201056180 | 0.6291132951 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1318262742 |
| GSE13712_SHEAR | Up | 0.3262427003 |
| GSE13712_STATIC | Up | 0.3803541850 |
| GSE19018 | Up | 0.4685711845 |
| GSE19899_A1 | Down | -0.3841235394 |
| GSE19899_A2 | Down | -0.0032844325 |
| PubMed_21979375_A1 | Down | -0.7223398443 |
| PubMed_21979375_A2 | Down | -0.1751633442 |
| GSE35957 | Up | 0.4836058945 |
| GSE36640 | Up | 0.9751616881 |
| GSE54402 | Up | 0.0428529930 |
| GSE9593 | Up | 0.2532170331 |
| GSE43922 | Down | -0.2940518124 |
| GSE24585 | Down | -0.2849563027 |
| GSE37065 | Down | -0.2041790724 |
| GSE28863_A1 | Down | -0.1132965726 |
| GSE28863_A2 | Up | 0.5971060017 |
| GSE28863_A3 | Down | -0.3667418830 |
| GSE28863_A4 | Down | -0.3696908840 |
| GSE48662 | Down | -0.2067297674 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Compound | Target | Confidence score | Uniprot |
|---|---|---|---|
| CHEMBL369996 | CHEMBL3495 | 9 | P48163 |
| CHEMBL202332 | CHEMBL3495 | 9 | P48163 |
| CHEMBL201911 | CHEMBL3495 | 9 | P48163 |
| CHEMBL201154 | CHEMBL3495 | 9 | P48163 |
| CHEMBL202380 | CHEMBL3495 | 9 | P48163 |
| CHEMBL372408 | CHEMBL3495 | 9 | P48163 |
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025454 | Proteomics | Functional MTI (Weak) | 21566225 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23334421 | We show that p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells |
| 23334421 | Downregulation of ME1 and ME2 reciprocally activates p53 through distinct MDM2- and AMP-activated protein kinase-mediated mechanisms in a feed-forward manner, bolstering this pathway and enhancing p53 activation |
| 23334421 | Downregulation of ME1 and ME2 also modulates the outcome of p53 activation, leading to strong induction of senescence, but not apoptosis, whereas enforced expression of either malic enzyme suppresses senescence |
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