HCSGD entry for MDH2
1. General information
| Official gene symbol | MDH2 |
|---|---|
| Entrez ID | 4191 |
| Gene full name | malate dehydrogenase 2, NAD (mitochondrial) |
| Other gene symbols | M-MDH MDH MGC:3559 MOR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | TAS | biological_process |
| GO:0006099 | Tricarboxylic acid cycle | IEA TAS | biological_process |
| GO:0006107 | Oxaloacetate metabolic process | IEA | biological_process |
| GO:0006108 | Malate metabolic process | IDA IEA IMP | biological_process |
| GO:0006475 | Internal protein amino acid acetylation | IDA | biological_process |
| GO:0006734 | NADH metabolic process | IEA | biological_process |
| GO:0030060 | L-malate dehydrogenase activity | EXP IDA IEA IMP | molecular_function |
| GO:0043621 | Protein self-association | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046554 | Malate dehydrogenase (NADP+) activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4858289959 | 0.4918991110 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2145547420 |
| GSE13712_SHEAR | Up | 0.0679455629 |
| GSE13712_STATIC | Up | 0.0138395318 |
| GSE19018 | Down | -0.3649580807 |
| GSE19899_A1 | Down | -0.1044004051 |
| GSE19899_A2 | Up | 0.5973510936 |
| PubMed_21979375_A1 | Down | -0.0526829510 |
| PubMed_21979375_A2 | Up | 0.2820442987 |
| GSE35957 | Down | -0.0799036859 |
| GSE36640 | Up | 0.4029618838 |
| GSE54402 | Down | -0.1367993060 |
| GSE9593 | Up | 0.0475347635 |
| GSE43922 | Up | 0.1446367433 |
| GSE24585 | Down | -0.3337044136 |
| GSE37065 | Down | -0.1758882575 |
| GSE28863_A1 | Up | 0.1121833432 |
| GSE28863_A2 | Up | 0.1623638509 |
| GSE28863_A3 | Up | 0.1408885127 |
| GSE28863_A4 | Down | -0.2404960991 |
| GSE48662 | Down | -0.2938754155 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1301-3p | MIMAT0005797 | MIRT035981 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039952 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041283 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041647 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-3p | MIMAT0001343 | MIRT042426 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044824 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046217 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046682 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 2782845 | No changes were found with ageing in inner mitochondrial membrane-associated matrix components, or in the activities of O-S ATPase and MDH |
| 6934772 | Electrophoretic mobilities of malic dehydrogenase (MDH) were assayed in 11 stocks of Paramecium tetraurelia by polyacrylamide gel electrophoresis |
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